Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

被引：63

作者：

Begenisic, Tatjana ^{[1
]}

Spolidoro, Maria ^{[1
]}

Braschi, Chiara ^{[2
]}

Baroncelli, Laura ^{[3
]}

Milanese, Marco ^{[4
]}

Pietra, Gianluca ^{[3
]}

Fabbri, Maria E. ^{[3
]}

Bonanno, Giambattista ^{[4
]}

Cioni, Giovanni ^{[5
,6
]}

Maffei, Lamberto ^{[1
,3
]}

Sale, Alessandro ^{[3
]}

机构：

[1] Scuola Normale Super Pisa, Neurobiol Lab, Pisa, Italy

[2] Univ Florence, Dept Psychol, Florence, Italy

[3] CNR, Inst Neurosci, I-56100 Pisa, Italy

[4] Univ Genoa, Dept Expt Med, Sect Pharmacol & Toxicol, Genoa, Italy

[5] IRCCS Stella Maris, Dept Dev Neurosci, Pisa, Italy

[6] Univ Pisa, Pisa, Italy

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2011年 / 5卷

关键词：

Down syndrome; Ts65Dn mice; environmental enrichment; GABAergic inhibition; cerebral plasticity; OCULAR DOMINANCE PLASTICITY; LONG-TERM POTENTIATION; TS65DN MOUSE; NEURODEVELOPMENTAL DISORDERS; INTRACORTICAL INHIBITION; BEHAVIORAL-ASSESSMENT; ALZHEIMERS-DISEASE; MICE; AMBLYOPIA; CHILDREN;

D O I：

10.3389/fncel.2011.00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Down syndrome (DS) is the most common genetic disorder associated with mental retardation. It has been repeatedly shown that Ts65Dn mice, the prime animal model for DS, have severe cognitive and neural plasticity defects due to excessive inhibition. We report that increasing sensory-motor stimulation in adulthood through environmental enrichment (EE) reduces brain inhibition levels and promotes recovery of spatial memory abilities, hippocampal synaptic plasticity, and visual functions in adult Ts65Dn mice.

引用

页码：1 / 22

页数：9

共 54 条

[21] Spatial vision deficits in infants and children with Down syndrome [J].

John, FM ;

Bromham, NR ;

Woodhouse, JM ;

Candy, TR .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (05) :1566-1572

[22]

Kleschevnikov A. M., 2011, NEUROBIOL DIS

[23] Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome [J].

Kleschevnikov, AM ;

Belichenko, PV ;

Villar, AJ ;

Epstein, CJ ;

Malenka, RC ;

Mobley, WC .

JOURNAL OF NEUROSCIENCE, 2004, 24 (37) :8153-8160

[24]

LEJEUNE J, 1959, CR HEBD ACAD SCI, V248, P1721

[25] The eye and Down's syndrome [J].

Liyanage, Sidath ;

Bames, Jonathan .

BRITISH JOURNAL OF HOSPITAL MEDICINE, 2008, 69 (11) :632-634

[26] Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome [J].

Martínez-Cué, C ;

Rueda, N ;

García, E ;

Davisson, MT ;

Schmidt, C ;

Flórez, J .

BEHAVIOURAL BRAIN RESEARCH, 2005, 163 (02) :174-185

[27] Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome [J].

Martínez-Cué, C ;

Baamonde, C ;

Lumbreras, M ;

Paz, J ;

Davisson, MT ;

Schmidt, C ;

Dierssen, M ;

Flórez, J .

BEHAVIOURAL BRAIN RESEARCH, 2002, 134 (1-2) :185-200

[28] The antidepressant fluoxetine restores plasticity in the adult visual cortex [J].

Maya-Vetencourt, Jose Fernando ;

Sale, Alessandro ;

Viegi, Alessandro ;

Baroncelli, Laura ;

De Pasquale, Roberto ;

O'Leary, Olivia F. ;

Castren, Eero ;

Maffei, Lamberto .

SCIENCE, 2008, 320 (5874) :385-388

[29] Down syndrome, Alzheimer's disease and seizures [J].

Menéndez, M .

BRAIN & DEVELOPMENT, 2005, 27 (04) :246-252

[30] The power of comparative and developmental studies for mouse models of Down syndrome [J].

Moore, Clara S. ;

Roper, Randall J. .

MAMMALIAN GENOME, 2007, 18 (6-7) :431-443

← 1 2 3 4 5 6 →