Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

被引：62

作者：

Begenisic, Tatjana ^{[1
]}

Spolidoro, Maria ^{[1
]}

Braschi, Chiara ^{[2
]}

Baroncelli, Laura ^{[3
]}

Milanese, Marco ^{[4
]}

Pietra, Gianluca ^{[3
]}

Fabbri, Maria E. ^{[3
]}

Bonanno, Giambattista ^{[4
]}

Cioni, Giovanni ^{[5
,6
]}

Maffei, Lamberto ^{[1
,3
]}

Sale, Alessandro ^{[3
]}

机构：

[1] Scuola Normale Super Pisa, Neurobiol Lab, Pisa, Italy

[2] Univ Florence, Dept Psychol, Florence, Italy

[3] CNR, Inst Neurosci, I-56100 Pisa, Italy

[4] Univ Genoa, Dept Expt Med, Sect Pharmacol & Toxicol, Genoa, Italy

[5] IRCCS Stella Maris, Dept Dev Neurosci, Pisa, Italy

[6] Univ Pisa, Pisa, Italy

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2011年 / 5卷

关键词：

Down syndrome; Ts65Dn mice; environmental enrichment; GABAergic inhibition; cerebral plasticity; OCULAR DOMINANCE PLASTICITY; LONG-TERM POTENTIATION; TS65DN MOUSE; NEURODEVELOPMENTAL DISORDERS; INTRACORTICAL INHIBITION; BEHAVIORAL-ASSESSMENT; ALZHEIMERS-DISEASE; MICE; AMBLYOPIA; CHILDREN;

D O I：

10.3389/fncel.2011.00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Down syndrome (DS) is the most common genetic disorder associated with mental retardation. It has been repeatedly shown that Ts65Dn mice, the prime animal model for DS, have severe cognitive and neural plasticity defects due to excessive inhibition. We report that increasing sensory-motor stimulation in adulthood through environmental enrichment (EE) reduces brain inhibition levels and promotes recovery of spatial memory abilities, hippocampal synaptic plasticity, and visual functions in adult Ts65Dn mice.

引用

页码：1 / 22

页数：9

共 54 条

[1] G-Protein-Associated Signal Transduction Processes Are Restored after Postweaning Environmental Enrichment in Ts65Dn, a Down Syndrome Mouse Model [J].

Baamonde, C. ;

Martinez-Cue, C. ;

Florez, J. ;

Dierssen, M. .

DEVELOPMENTAL NEUROSCIENCE, 2011, 33 (05) :442-450

[2] Nurturing brain plasticity: impact of environmental enrichment [J].

Baroncelli, L. ;

Braschi, C. ;

Spolidoro, M. ;

Begenisic, T. ;

Sale, A. ;

Maffei, L. .

CELL DEATH AND DIFFERENTIATION, 2010, 17 (07) :1092-1103

[3] Brain Plasticity and Disease: A Matter of Inhibition [J].

Baroncelli, Laura ;

Braschi, Chiara ;

Spolidoro, Maria ;

Begenisic, Tatjana ;

Maffei, Lamberto ;

Sale, Alessandro .

NEURAL PLASTICITY, 2011, 2011

[4] Experience-dependent reactivation of ocular dominance plasticity in the adult visual cortex [J].

Baroncelli, Laura ;

Sale, Alessandro ;

Viegi, Alessandro ;

Maya-Vetencourt, Jose Fernando ;

De Pasquale, Roberto ;

Baldini, Sara ;

Maffei, Lamberto .

EXPERIMENTAL NEUROLOGY, 2010, 226 (01) :100-109

[5] Excitatory-Inhibitory Relationship in the Fascia Dentata in the Ts65Dn Mouse Model of Down Syndrome [J].

Belichenko, Pavel V. ;

Klescrevnikov, Alexander M. ;

Masliah, Eliezer ;

Wu, Chengbiao ;

Takimoto-Kimura, Ryoko ;

Salehi, Ahmad ;

Mobley, William C. .

JOURNAL OF COMPARATIVE NEUROLOGY, 2009, 512 (04) :453-466

[6] Synaptic structural abnormalities in the Ts65Dn mouse model of Down syndrome [J].

Belichenko, PV ;

Masliah, E ;

Kleschevnikov, AM ;

Villar, AJ ;

Epstein, CJ ;

Salehi, A ;

Mobley, WC .

JOURNAL OF COMPARATIVE NEUROLOGY, 2004, 480 (03) :281-298

[7] The Down Syndrome Critical Region Regulates Retinogeniculate Refinement [J].

Blank, Martina ;

Fuerst, Peter G. ;

Stevens, Beth ;

Nouri, Navid ;

Kirkby, Lowry ;

Warrier, Deepti ;

Barres, Ben A. ;

Feller, Marla B. ;

Huberman, Andrew D. ;

Burgess, Robert W. ;

Garner, Craig C. .

JOURNAL OF NEUROSCIENCE, 2011, 31 (15) :5764-5776

[8] Spatial representation and attention in toddlers with Williams syndrome and Down syndrome [J].

Brown, JH ;

Johnson, MH ;

Paterson, SJ ;

Gilmore, R ;

Longhi, E ;

Karmiloff-Smith, A .

NEUROPSYCHOLOGIA, 2003, 41 (08) :1037-1046

[9] Environmental Enrichment Rescues Postnatal Neurogenesis Defect in the Male and Female Ts65Dn Mouse Model of Down Syndrome [J].

Chakrabarti, Lina ;

Scafidi, Joseph ;

Gallo, Vittorio ;

Haydar, Tarik F. .

DEVELOPMENTAL NEUROSCIENCE, 2011, 33 (05) :428-441

[10] Behavioral assessment of children with Down syndrome using the Reiss psychopathology scale [J].

Clark, D ;

Wilson, GN .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2003, 118A (03) :210-216

← 1 2 3 4 5 6 →