A prospective survey of febrile events in hematological malignancies

被引：50

作者：

Pagano, L. ^{[1
]}

Caira, M. ^{[1
]}

Rossi, G. ^{[2
,13
,14
,15
]}

Tumbarello, M. ^{[3
]}

Fanci, R.

Garzia, M. G. ^{[4
]}

Vianelli, N.

Filardi, N. ^{[5
]}

De Fabritiis, P. ^{[6
]}

Beltrame, A. ^{[7
]}

Musso, M. ^{[8
,9
]}

Piccin, A. ^{[10
]}

Cuneo, A. ^{[11
]}

Cattaneo, C. ^{[2
]}

Aloisi, T. ^{[12
]}

Riva, M. ^{[13
,14
]}

Rossi, G. ^{[2
,13
,14
,15
]}

Salvadori, U. ^{[16
]}

Brugiatelli, M. ^{[17
]}

Sannicolo, S. ^{[18
]}

Morselli, M. ^{[19
]}

Bonini, A. ^{[20
]}

Viale, P. ^{[21
]}

Nosari, A.

Aversa, F. ^{[12
]}

机构：

[1] Univ Cattolica Sacro Cuore, Ist Ematol, Largo Francesco Vito 1, I-00168 Rome, Italy

[2] UO Ematol, Spedali Civili, Brescia, Italy

[3] Univ Cattolica Sacro Cuore, Ist Malattie Infett, Rome, Italy

[4] Div Ematol Az Osp S Camillo Forlanini, Rome, Italy

[5] Azienda Osp Osp S Carlo, Potenza, Italy

[6] Osped S Eugenio, Rome, Italy

[7] Pol Univ Tor Vergata, Rome, Italy

[8] Dipartimento Ematoncol, Palermo, Italy

[9] Unit Trap Mid Osseo, Palermo, Italy

[10] Osped Generale Bolzano, Div Ematol, Bologna, Italy

[11] Az Osp Univ Arcispedale S Anna, Ist Ematol, Ferrara, Italy

[12] Univ Perugia, Ist Ematol, Perugia, Italy

[13] Osped Niguarda Ca Granda, Div Ematol, Milan, Italy

[14] Osped Niguarda Ca Granda, Ctr Trapianti Midollo, Milan, Italy

[15] IRCCS Casa Sollievo Sofferenza, Unit Ematol, San Giovanni Rotondo, Italy

[16] Osped Civile Ca Foncello, Div Ematol, Treviso, Italy

[17] Osped Papardo, Messina, Italy

[18] Umberto 1, Div Ematol, Venice, Italy

[19] Policlin Univ Modena Reggio, Div Ematol, Modena, Italy

[20] Arciospedale S Maria Nuova, Div Ematol, Reggio Emilia, Italy

[21] Univ Bologna, Clin Malattie Infett, Bologna, Italy

来源：

ANNALS OF HEMATOLOGY | 2012年 / 91卷 / 05期

关键词：

Epidemiology; Hematological malignancies; Febrile events; Registry; STEM-CELL TRANSPLANT; FUNGAL-INFECTIONS; NEUTROPENIC PATIENTS; INVASIVE ASPERGILLOSIS; ANTIMICROBIAL AGENTS; EPIDEMIOLOGY; MANAGEMENT; RECIPIENTS; PNEUMONIA; MORTALITY;

D O I：

10.1007/s00277-011-1373-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.

引用

页码：767 / 774

页数：8

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