Targeting the Wnt/ββ-catenin signaling pathway in human cancers

被引：170
|
作者：
Yao, Hisayuki [1 ]
Ashihara, Eishi [1 ,2 ]
Maekawa, Taira [1 ]
机构：
[1] Kyoto Univ Hosp, Dept Transfus Med & Cell Therapy, Sakyo Ku, Kyoto 6068507, Japan
[2] Kyoto Prefectural Univ Med, Dept Mol Cell Physiol, Kamigyo Ku, Kyoto 6028566, Japan
来源：
EXPERT OPINION ON THERAPEUTIC TARGETS | 2011年 / 15卷 / 07期
关键词：
cancer; cancer stem cell; high-throughput screening; Wnt; beta-catenin; FREQUENT EPIGENETIC INACTIVATION; SMALL-MOLECULE ANTAGONISTS; FRIZZLED-RELATED PROTEIN-1; ENDOTHELIAL GROWTH-FACTOR; INHIBITORY FACTOR-I; F-BOX PROTEIN; COLORECTAL-CANCER; WNT PATHWAY; STEM-CELLS; PROMOTER HYPERMETHYLATION;
D O I：
10.1517/14728222.2011.577418
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Areas covered: This review discusses the potential of inhibiting the Wnt/beta beta-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. Expert opinion: Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/beta beta-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/beta beta-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/beta beta-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.
引用
收藏
页码：873 / 887
页数：15
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