Targeting the Wnt/ββ-catenin signaling pathway in human cancers

被引：170

作者：

Yao, Hisayuki ^{[1
]}

Ashihara, Eishi ^{[1
,2
]}

Maekawa, Taira ^{[1
]}

机构：

[1] Kyoto Univ Hosp, Dept Transfus Med & Cell Therapy, Sakyo Ku, Kyoto 6068507, Japan

[2] Kyoto Prefectural Univ Med, Dept Mol Cell Physiol, Kamigyo Ku, Kyoto 6028566, Japan

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2011年 / 15卷 / 07期

关键词：

cancer; cancer stem cell; high-throughput screening; Wnt; beta-catenin; FREQUENT EPIGENETIC INACTIVATION; SMALL-MOLECULE ANTAGONISTS; FRIZZLED-RELATED PROTEIN-1; ENDOTHELIAL GROWTH-FACTOR; INHIBITORY FACTOR-I; F-BOX PROTEIN; COLORECTAL-CANCER; WNT PATHWAY; STEM-CELLS; PROMOTER HYPERMETHYLATION;

D O I：

10.1517/14728222.2011.577418

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Areas covered: This review discusses the potential of inhibiting the Wnt/beta beta-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. Expert opinion: Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/beta beta-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/beta beta-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/beta beta-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.

引用

页码：873 / 887

页数：15

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