In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer

被引：205
作者：
Itharat, A
Houghton, PJ
Eno-Amooquaye, E
Burke, PJ
Sampson, JH
Raman, A
机构：
[1] Univ London Kings Coll, Dept Pharm, Pharmacognosy Res Labs, London SE1 9NN, England
[2] Prince Songkha Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Hat Yai 90110, Songkhla, Thailand
[3] Charing Cross Hosp, Dept Med Oncol, London W6 8RF, England
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 90卷 / 01期
关键词：
dioscorea; siphonodon; cytotoxicity test; SRB assay; Thai anticancer plants;
D O I：
10.1016/j.jep.2003.09.014
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The SRB assay was used to test cytotoxicity against three human cancer cell lines and one normal cell line of I I Thai medicinal plant species used by traditional doctors in treating cancer patients. The extraction procedures used were similar to those practised by Thai traditional doctors (ethanolic and water extracts). Extracts were tested against the human large cell lung carcinoma cell line COR-L23, the human breast adenocarcinoma cell line MCF-7 and human colon adenocarcinoma cell line LS-174T and normal human keratinocytes SVK-14. The results showed that three plants; Dioscorea membranacea Pierre ex Prain & Burkill, Dioscorea birmanica Prain & Burkill (Dioscoreaceae) and Siphonodon celastrineus Griff. (Celastraceae), exhibited high cytotoxic activity showing a certain degree of selectivity against the different cell types. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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页码：33 / 38
页数：6
相关论文
共 23 条
[1]  
Boonyaratanakornkit L, 1993, THAI J PHARM SCI, V1, P79
[2]  
CARDELLINA II, 1999, BIOASSAAY METHOD NAT, P25
[3]  
Chayamarit K., 1995, THAI MED PLANTS, P720
[4]   A new flavanone isolated from rhizoma Smilacis glabrae and the structural requirements of its derivatives for preventing immunological hepatocyte damage [J].
Chen, T ;
Li, JX ;
Cao, JS ;
Xu, Q ;
Komatsu, K ;
Namba, T .
PLANTA MEDICA, 1999, 65 (01) :56-59
[5]  
HALLIWELL B, 1988, FREE RADICAL BIO MED, P481
[6]  
HENRY N, 1923, THAI FLORA MALAY PEN
[7]  
Itharat A., 2002, FOLK WISDOM TREATMEN, P83
[8]  
Itharat A., 1999, SURVEY MED PLANTS LO, P82
[9]  
Itharat A, 1998, WISDOM SO THAI TRADI, P126
[10]  
ITHARAT A, 1999, IDENTIFICATION SPECI, P9
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