Towards the total synthesis of stawamycin. Synthesis of C11-C21 fragment.

被引：7

作者：

Dias, LC ^{[1
]}

Jardim, LSA ^{[1
]}

Ferreira, AA ^{[1
]}

Soarez, HU ^{[1
]}

机构：

[1] Univ Estadual Campinas, Inst Quim, BR-13083970 Campinas, SP, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2001年 / 12卷 / 04期

关键词：

intramolecular Diels-Alder reaction; Stille coupling; herpes virus inhibitor;

D O I：

10.1590/S0103-50532001000400003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The carbocyclic (C11-C21) fragment of Stawamycin has been prepared by a sequence involving 11 steps (10% overall yield) from methyl (R)-(-)-3-hydroxy-2-methylpropionate. Key steps are Pd-catalyzed Stille coupling reaction between a vinyl iodide and a vinylstannane followed by an intramolecular Diels-Alder cycloaddition reaction to afford the desired adduct as the major isomer together with three other possible adducts in 78% overall yield.

引用

页码：463 / 466

页数：4

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