Well-ordered mesoporous silica nanoparticles as cell markers

被引：376
作者：
Lin, YS
Tsai, CP
Huang, HY
Kuo, CT
Hung, Y [1 ]
Huang, DM
Chen, YC
Mou, CY
机构：
[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
[2] Natl Hlth Res Inst, Stem Cell Res Ctr, Taipei 115, Taiwan
[3] Natl Taiwan Univ, Ctr Condensed Matter Sci, Taipei 106, Taiwan
来源：
CHEMISTRY OF MATERIALS | 2005年 / 17卷 / 18期
关键词：
D O I：
10.1021/cm051014c
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells.
引用
收藏
页码：4570 / 4573
页数：4
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