The Role of Histamine in Ocular Allergy

被引：0
作者：
Ohbayashi, Masaharu
Manzouri, Bita [2 ]
Morohoshi, Kei
Fukuda, Ken
Ono, Santa J. [1 ]
机构：
[1] Emory Univ, Dept Ophthalmol, Emory Eye Ctr, Off Provost, Atlanta, GA 30322 USA
[2] Moorfields Eye Hosp, Dept Cornea & External Dis, London, England
来源：
HISTAMINE IN INFLAMMATION | 2010年 / 709卷
关键词：
TOPICAL TACROLIMUS; MAST-CELLS; CONJUNCTIVITIS; PHARMACOLOGY; ANTAGONISTS; EXPRESSION; DISORDERS; RECEPTORS; THERAPY; UPDATE;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Ocular allergy is a disorder affecting increasing numbers of individuals worldwide. Among the inflammatory mediators that contribute to ocular allergy, histamine is perhaps the best characterized. This monoamine is released by sensitized mast cells upon exposure to allergen and causes symptoms such as redness and tearing. Histamine may also recruit immune cells that can cause long-term damage to ocular surfaces. In this chapter we will discuss the known functions of histamine and histamine receptors in ocular allergy and will describe promising therapies targeting the histamine-signaling pathway.
引用
收藏
页码：43 / 52
页数：10
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