Biodegradable polymers for ocular drug delivery

被引：96
作者：
Kimura, H [1 ]
Ogura, Y [1 ]
机构：
[1] Nagoya City Univ, Sch Med, Dept Ophthalmol, Mizuho Ku, Nagoya, Aichi 4678601, Japan
来源：
OPHTHALMOLOGICA | 2001年 / 215卷 / 03期
关键词：
biodegradable; polymers; poly(lactic acid); poly(lactic-glycolic acid); vitreous; implant; microsphere; drug;
D O I：
10.1159/000050849
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
A variety of ocular drug delivery systems, including a controlled release of the drug, drug targeting, and penetration enhancement of the drug, have been investigated, Biodegradable polymers have been widely used as the drug carrier for controlled-release systems. Biodegradable polymers release the drug as they themselves degrade and are finally absorbed within the body. Several ocular drug delivery systems using different kinds of biodegradable polymers have been studied. In this article, we describe the fundamental mechanisms of drug delivery systems, polymer erosion and drug release, and then review those systems using the most popular biodegradable polymers, poly(lactic acid) and poly(lactic-glycolic acid). Copyright (C) 2001 S.Karger AG, Basel.
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收藏
页码：143 / 155
页数：13
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