EFFICIENT SYNTHESIS OF NEW FUNCTIONALIZED 2-(HETARYL)THIAZOLES

被引：16

作者：

Bondock, Samir ^{[1
,2
]}

El-Azab, Hossam ^{[1
]}

Kandeel, Ez-Eldin M. ^{[1
]}

Metwally, Mohamed A. ^{[1
]}

机构：

[1] Mansoura Univ, Dept Chem, Fac Sci, ET-35516 Mansoura, Egypt

[2] King Khalid Univ, Dept Chem, Fac Sci, Abha, Saudi Arabia

来源：

SYNTHETIC COMMUNICATIONS | 2013年 / 43卷 / 01期

关键词：

Japp-Klingmann; phenyl isothiocyanate; pyrazole; pyridine; thiazole; THIAZOLE; HETEROCYCLES; DERIVATIVES; ETHYL;

D O I：

10.1080/00397911.2011.591036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the hitherto unknown ring system, 2-heteroaryl-thiazoles, is described via the reaction of 3-oxo-N-(4-phenylthiazol-2-yl) butanamide (1) with diazotized heterocyclic amine, phenyl isothiocyanate, dimethylformamide-dimethylacetal, and hydrazine hydrate, and the reaction of 2-chloro-N-(4-phenylthiazol-2-yl) acetamide (13) with some sulfur nucleophiles and malononitrile. The structures of the compounds prepared were determined by analytical and spectral analyses.

引用

页码：59 / 71

页数：13

共 50 条

[21] SYNTHESIS AND EVALUATION FOR BIOLOGICAL ACTIVITIES OF 2-THIO-ACYLATED THIAZOLES CONTAINING PYRAZOLE MOIETY
Masumoto, Eiichi
Kashige, Nobuhiro
Nagabuchi, Hayate
Okabe-Nakahara, Fumi
Maruoka, Hiroshi
HETEROCYCLES, 2019, 98 (12) : 1736 - 1746
[22] A New Synthesis of Functionalized 2,2′-Biimidazoles
Stippich, Kevin
Kretschmer, Robert
Beckert, Rainer
Goerls, Helmar
SYNTHESIS-STUTTGART, 2010, (08): : 1311 - 1314
[23] Efficient synthesis of new 3-heteroaryl-1-functionalized 1H-indazoles
Fraile, Alberto
Rosario Martin, M.
Garcia Ruano, Jose Luis
Antonio Diaz, Juan
Arranz, Esther
TETRAHEDRON, 2011, 67 (01) : 100 - 105
[24] Synthesis and study of antibacterial and antifungal activities of Novel 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl] acetylamino]thiazoles
Zafer Asim Kaplancikli
Gülhan Turan-Zitouni
Gilbert Revial
Kiymet Guven
Archives of Pharmacal Research, 2004, 27 : 1081 - 1085
[25] Efficient Synthesis of 2,4-Disubstituted Thiazoles Under Grinding
Heravi, Majid M.
Poormohammad, Nargess
Beheshtiha, Yahia S.
Baghernejad, Bita
SYNTHETIC COMMUNICATIONS, 2011, 41 (04) : 579 - 582
[26] Four Components One-Pot Synthesis of New Thiazoles and Their Biological Screening for Anti-Tuberculosis Activity
Vijay, Kadam
Choudhare, Tukaram S.
Wagare, Devendra
Lingampalle, Dinesh
Netankar, Prashant D.
IRANIAN JOURNAL OF CHEMISTRY & CHEMICAL ENGINEERING-INTERNATIONAL ENGLISH EDITION, 2023, 42 (09): : 2840 - 2847
[27] Synthesis and study of antibacterial and antifungal activities of novel 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl] acetylamino]thiazoles
Kaplancikli, ZA
Turan-Zitouni, G
Revial, G
Guven, K
ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (11) : 1081 - 1085
[28] Synthesis and characterization of new pyrazole-based thiazoles
Abdelhamid, Abdou O.
Gomha, Sobhi M.
SYNTHETIC COMMUNICATIONS, 2017, 47 (15) : 1409 - 1414
[29] Synthesis of new substituted thiazoles containing aminooxadiazole ring
Danil'chuk, V. S.
Nezamaev, N. A.
El'zhurkaev, M. Kh.
Verigin, A. N.
RUSSIAN JOURNAL OF APPLIED CHEMISTRY, 2008, 81 (03) : 520 - 523
[30] Synthesis of new substituted thiazoles containing aminooxadiazole ring
O. V. Platonova
S. B. Volkova
S. A. Malin
E. A. Veretennikov
B. M. Laskin
A. S. Malin
Russian Journal of Applied Chemistry, 2008, 81

← 1 2 3 4 5 →