EFFICIENT SYNTHESIS OF NEW FUNCTIONALIZED 2-(HETARYL)THIAZOLES

被引：16
|
作者：
Bondock, Samir [1 ,2 ]
El-Azab, Hossam [1 ]
Kandeel, Ez-Eldin M. [1 ]
Metwally, Mohamed A. [1 ]
机构：
[1] Mansoura Univ, Dept Chem, Fac Sci, ET-35516 Mansoura, Egypt
[2] King Khalid Univ, Dept Chem, Fac Sci, Abha, Saudi Arabia
来源：
SYNTHETIC COMMUNICATIONS | 2013年 / 43卷 / 01期
关键词：
Japp-Klingmann; phenyl isothiocyanate; pyrazole; pyridine; thiazole; THIAZOLE; HETEROCYCLES; DERIVATIVES; ETHYL;
D O I：
10.1080/00397911.2011.591036
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of the hitherto unknown ring system, 2-heteroaryl-thiazoles, is described via the reaction of 3-oxo-N-(4-phenylthiazol-2-yl) butanamide (1) with diazotized heterocyclic amine, phenyl isothiocyanate, dimethylformamide-dimethylacetal, and hydrazine hydrate, and the reaction of 2-chloro-N-(4-phenylthiazol-2-yl) acetamide (13) with some sulfur nucleophiles and malononitrile. The structures of the compounds prepared were determined by analytical and spectral analyses.
引用
收藏
页码：59 / 71
页数：13
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