Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation

被引:28
作者
Jung, Sung A. [1 ]
Choi, Miseon [1 ]
Kim, Sohee [1 ]
Yu, Rina [2 ]
Park, Taesun [1 ]
机构
[1] Yonsei Univ, Dept Food & Nutr, Seoul 120749, South Korea
[2] Univ Ulsan, Dept Food Sci & Nutr, Ulsan 680749, South Korea
基金
新加坡国家研究基金会;
关键词
BETA-CATENIN; METABOLIC SYNDROME; OXIDATIVE STRESS; INNATE IMMUNITY; CELL FACTOR; RESISTANCE; RECEPTORS; ADIPOCYTES; MODULATION; ACTIVATION;
D O I
10.1155/2012/541204
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cinchonine (C19H22N2O) is a natural compound of Cinchona bark. Although cinchonine's antiplatelet effect has been reported in the previous study, antiobesity effect of cinchonine has never been studied. The main objective of this study was to investigate whether cinchonine reduces high-fat-diet- (HFD-) induced adipogenesis and inflammation in the epididymal fat tissues of mice and to explore the underlying mechanisms involved in these reductions. HFD- fed mice treated with 0.05% dietary cinchonine for 10 weeks had reduced body weight gain (-38%), visceral fat-pad weights (-26%), and plasma levels of triglyceride, free fatty acids, total cholesterol, and glucose compared with mice fed with the HFD. Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice. Cinchonine also attenuated the HFD- induced upregulation of proinflammatory cytokines by inhibiting toll-like-receptor-2- (TLR2-) and TLR4-mediated signaling cascades in the adipose tissue of mice. Our findings suggest that dietary cinchonine with its effects on adipogenesis and inflammation may have a potential benefit in preventing obesity.
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收藏
页数:11
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