Synthesis of Diverse α-Fluoroalkoxyaryl Derivatives and Their Use for the Generation of Fluorinated Macrocycles

被引：8

作者：

Cogswell, Thomas J. ^{[1
]}

Dahlen, Anders ^{[1
]}

Knerr, Laurent ^{[1
]}

机构：

[1] AstraZeneca R&D, Cardiovasc & Metab Dis, Innovat Med & Early Dev, SE-43189 Molndal, Sweden

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2019年 / 25卷 / 05期

关键词：

1,1-difluoroallylation; difluorinated; germinal fluorination; macrocycles; alpha-fluoroalkoxyaryl; BETA-PEPTIDES; CHEMISTRY; THIOETHERS; ACIDS; PHARMACEUTICALS; 3(14)-HELIX; AMINES; TRENDS; ETHERS;

D O I：

10.1002/chem.201804440

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Introduction of difluorinated functionality has emerged as a powerful means for conformational design with minimal steric footprint. Synthetic approaches for the preparation of aryl difluoromethylene ether containing novel building blocks were established, enabling the inclusion of the aryl difluoromethylene ether system into macrocyclic scaffolds for the first time.

引用

页码：1184 / 1187

页数：4

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