A Novel Skin Substitute Biomaterial to Treat Full-Thickness Wounds in a Burns Emergency Care

被引：2

作者：

Shevchenko, R. V. ^{[1
]}

Sibbons, P. D. ^{[3
]}

Sharpe, J. R. ^{[2
]}

James, S. E. ^{[1
]}

机构：

[1] Univ Brighton, Sch Pharm & Biomol Sci, Brighton BN2 4GJ, E Sussex, England

[2] Blond McIndoe Res Fdn, Queen Victoria Hosp, E Grinstead, E Sussex RH19 3DZ, England

[3] Northwick Pk Inst Med Res, Harrow HA1 3UJ, Middx, England

来源：

BIODEFENCE: ADVANCED MATERIALS AND METHODS FOR HEALTH PROTECTION | 2011年

关键词：

Permacol; Integra; Skin substitute; Dermal substitute; Cultured keratinocytes; Collagen; Animal model; CULTURED EPITHELIAL AUTOGRAFT; ENGINEERED SKIN; KERATINOCYTES; INJURIES; CLOSURE;

D O I：

10.1007/978-94-007-0217-2_25

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel porcine collagen-based paste dermal substitute to treat full-thickness wounds has been investigated. A thin split-thickness skin graft or autologous cultured keratinocytes have been combined with dermal replacement biomaterial and applied to full-thickness wounds in a porcine wound chamber preclinical experimental model. The data obtained suggest that: ( I) dermal substitute biomaterials may improve wound re-epithelialisation when combined with cultured autologous keratinocytes and (2) porcine collagen paste is able to support split-thickness skin graft survival as well as autologous cultured keratinocyte proliferation. These results demonstrate that the novel porcine collagen paste has a potential as a dermal substitute to treat acute full-thickness wounds and an application for the burns emergency care treatment.

引用

页码：247 / +

页数：3

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