The Dynamics of the Antimicrobial Resistance Mobilome of Salmonella enterica and Related Enteric Bacteria

被引：28

作者：

Algarni, Suad ^{[1
,2
]}

Ricke, Steven C. ^{[3
]}

Foley, Steven L. ^{[1
,2
]}

Han, Jing ^{[1
]}

机构：

[1] FDA Natl Ctr Toxicol Res, Div Microbiol, Jefferson, AR USA

[2] Univ Arkansas, Cellular & Mol Biol Grad Program, Fayetteville, AR USA

[3] Univ Wisconsin, Dept Anim & Dairy Sci, Meat Sci & Anim Biol Discovery Program, Madison, WI USA

来源：

FRONTIERS IN MICROBIOLOGY | 2022年 / 13卷

关键词：

mobilome; conjugation; mobile genetic elements; Salmonella enterica; horizontal gene transfer; SPECTRUM-BETA-LACTAMASE; GENOMIC ISLAND SGI1; SEROVAR TYPHIMURIUM VIRULENCE; ANTIBIOTIC-RESISTANCE; INCHI2; PLASMIDS; CONJUGATIVE ELEMENTS; GENETIC ELEMENTS; INCA/C PLASMIDS; UNITED-STATES; MOLECULAR CHARACTERIZATION;

D O I：

10.3389/fmicb.2022.859854

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The foodborne pathogen Salmonella enterica is considered a global public health risk. Salmonella enterica isolates can develop resistance to several antimicrobial drugs due to the rapid spread of antimicrobial resistance (AMR) genes, thus increasing the impact on hospitalization and treatment costs, as well as the healthcare system. Mobile genetic elements (MGEs) play key roles in the dissemination of AMR genes in S. enterica isolates. Multiple phenotypic and molecular techniques have been utilized to better understand the biology and epidemiology of plasmids including DNA sequence analyses, whole genome sequencing (WGS), incompatibility typing, and conjugation studies of plasmids from S. enterica and related species. Focusing on the dynamics of AMR genes is critical for identification and verification of emerging multidrug resistance. The aim of this review is to highlight the updated knowledge of AMR genes in the mobilome of Salmonella and related enteric bacteria. The mobilome is a term defined as all MGEs, including plasmids, transposons, insertion sequences (ISs), gene cassettes, integrons, and resistance islands, that contribute to the potential spread of genes in an organism, including S. enterica isolates and related species, which are the focus of this review.

引用

页数：19

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