Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors

被引:1
作者
Gronnier, Julien [1 ,2 ,3 ,6 ]
Franck, Christina M. [1 ,2 ]
Stegmann, Martin [3 ,7 ]
DeFalco, Thomas A. [1 ,2 ,3 ]
Abarca, Alicia [1 ,2 ]
von Arx, Michelle [1 ,2 ]
Duenser, Kai [4 ]
Lin, Wenwei [5 ]
Yang, Zhenbiao [5 ]
Kleine-Vehn, Juergen [4 ]
Ringli, Christoph [1 ,2 ]
Zipfel, Cyril [1 ,2 ,3 ]
机构
[1] Univ Zurich, Inst Plant & Microbial Biol, Zurich, Switzerland
[2] Univ Zurich, Zurich Basel Plant Sci Ctr, Zurich, Switzerland
[3] Univ East Anglia, Sainsbury Lab, Norwich Res Pk, Norwich, Norfolk, England
[4] Univ Nat Resources & Life Sci Vienna, Dept Appl Genet & Cell Biol, Vienna, Austria
[5] Fujian Agr & Forestry Univ, FAFU UCR Joint Ctr Hort Biol & Metabol Ctr, Haixia Inst Sci & Technol, Fuzhou, Peoples R China
[6] Univ Tubingen, Ctr Plant Mol Biol ZMBP, Tubingen, Germany
[7] Tech Univ Munich, Sch Life Sci Weihenstephan, Phytopathol, Freising Weihenstephan, Germany
来源
ELIFE | 2022年 / 11卷
基金
奥地利科学基金会; 瑞士国家科学基金会; 欧盟地平线“2020”;
关键词
receptor kinase; plasma membrane; signaling; nanoscale organization; peptide hormones; innate immunity; A; thaliana; SINGLE-PARTICLE TRACKING; CELL-WALL INTEGRITY; STRUCTURAL BASIS; LATERAL DIFFUSION; INNATE IMMUNITY; LRX PROTEINS; PERCEPTION; FLS2; RECOGNITION; ACTIVATION;
D O I
10.7554/eLife.74162; 10.7554/eLife.74162.sa0; 10.7554/eLife.74162.sa1; 10.7554/eLife.74162.sa2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Spatial partitioning is a propensity of biological systems orchestrating cell activities in space and time. The dynamic regulation of plasma membrane nano-environments has recently emerged as a key fundamental aspect of plant signaling, but the molecular components governing it are still mostly unclear. The receptor kinase FERONIA (FER) controls ligand-induced complex formation of the immune receptor kinase FLAGELLIN SENSING 2 (FLS2) with its co-receptor BRASSINOSTEROID-INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1), and perception of the endogenous peptide hormone RAPID ALKALANIZATION FACTOR 23 (RALF23) by FER inhibits immunity. Here, we show that FER regulates the plasma membrane nanoscale organization of FLS2 and BAK1. Our study demonstrates that akin to FER, leucine-rich repeat (LRR) extensin proteins (LRXs) contribute to RALF23 responsiveness and regulate BAK1 nanoscale organization and immune signaling. Furthermore, RALF23 perception leads to rapid modification of FLS2 and BAK1 nanoscale organization, and its inhibitory activity on immune signaling relies on FER kinase activity. Our results suggest that perception of RALF peptides by FER and LRXs actively modulates plasma membrane nanoscale organization to regulate cell surface signaling by other ligand-binding receptor kinases.
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页数:20
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共 58 条
  • [1] Family-wide evaluation of RAPID ALKALINIZATION FACTOR peptides
    Abarca, Alicia
    Franck, Christina M.
    Zipfel, Cyril
    [J]. PLANT PHYSIOLOGY, 2021, 187 (02) : 996 - 1010
  • [2] Regulation of lipid saturation without sensing membrane fluidity
    Ballweg, Stephanie
    Sezgin, Erdinc
    Doktorova, Milka
    Covino, Roberto
    Reinhard, John
    Wunnicke, Dorith
    Haenelt, Inga
    Levental, Ilya
    Hummer, Gerhard
    Ernst, Robert
    [J]. NATURE COMMUNICATIONS, 2020, 11 (01)
  • [3] The chimeric leucine-rich repeat/extensin cell wall protein LRX1 is required for root hair morphogenesis in Arabidopsis thaliana
    Baumberger, N
    Ringli, C
    Keller, B
    [J]. GENES & DEVELOPMENT, 2001, 15 (09) : 1128 - 1139
  • [4] The walls have ears: the role of plant CrRLK1Ls in sensing and transducing extracellular signals
    Boisson-Dernier, Aurelien
    Kessler, Sharon A.
    Grossniklaus, Ueli
    [J]. JOURNAL OF EXPERIMENTAL BOTANY, 2011, 62 (05) : 1581 - 1591
  • [5] Visualization of BRI1 and BAK1(SERK3) Membrane Receptor Heterooligomers during Brassinosteroid Signaling
    Bucherl, Christoph A.
    van Esse, G. Wilma
    Kruis, Alex
    Luchtenberg, Jeroen
    Westphal, Adrie H.
    Aker, Jose
    van Hoek, Arie
    Albrecht, Catherine
    Borst, Jan Willem
    de Vries, Sacco C.
    [J]. PLANT PHYSIOLOGY, 2013, 162 (04) : 1911 - 1925
  • [6] Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains
    Buecherl, Christoph A.
    Jarsch, Iris K.
    Schudoma, Christian
    Segonzac, Cecile
    Mbengue, Malik
    Robatzek, Silke
    MacLean, Daniel
    Ott, Thomas
    Zipfel, Cyril
    [J]. ELIFE, 2017, 6
  • [7] A kinase-dead version of FERONIA receptor-like kinase has dose-dependent impacts on rosette morphology and RALF1-mediated stomatal movements
    Chakravorty, David
    Yu, Yunqing
    Assmann, Sarah M.
    [J]. FEBS LETTERS, 2018, 592 (20): : 3429 - 3437
  • [8] A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence
    Chinchilla, Delphine
    Zipfel, Cyril
    Robatzek, Silke
    Kemmerling, Birgit
    Nuernberger, Thorsten
    Jones, Jonathan D. G.
    Felix, Georg
    Boller, Thomas
    [J]. NATURE, 2007, 448 (7152) : 497 - U12
  • [9] Cell wall contributes to the stability of plasma membrane nanodomain organization of Arabidopsis thaliana FLOTILLIN2 and HYPERSENSITIVE INDUCED REACTION1 proteins
    Danek, Michal
    Angelini, Jindriska
    Malinska, Katerina
    Andrejch, Jan
    Amlerova, Zuzana
    Kocourkova, Daniela
    Brouzdova, Jitka
    Valentova, Olga
    Martinec, Jan
    Petrasek, Jan
    [J]. PLANT JOURNAL, 2020, 101 (03) : 619 - 636
  • [10] Molecular mechanisms of early plant pattern-triggered immune signaling
    DeFalco, Thomas A.
    Zipfel, Cyril
    [J]. MOLECULAR CELL, 2021, 81 (17) : 3449 - 3467