Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death

被引:25
|
作者
Hosoi, Toru [1 ]
Kakimoto, Mai [1 ]
Tanaka, Keigo [1 ]
Nomura, Jun [2 ]
Ozawa, Koichiro [1 ]
机构
[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pharmacotherapy, 1-2-3 Kasumi, Hiroshima 7348553, Japan
[2] RIKEN Brain Sci Inst, 2-1 Hirosawa, Wako, Saitama 3510198, Japan
关键词
Amyloid beta; Alzheimer's disease; ISRIB; ALZHEIMERS-DISEASE; PROTEIN; STRESS; EIF2-ALPHA; SIGNAL; GENE;
D O I
10.1016/j.jphs.2016.08.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid beta-induced neuronal cell death at concentrations of 12.5-25 nM, but did not inhibit amyloid beta production in the HEK293T cell line expressing the amyloid precursor protein (APP). These results suggest that ISRIB possesses the unique pharmacological property of attenuating amyloid beta-induced neuronal cell death without affecting amyloid b production. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
引用
收藏
页码:292 / 295
页数:4
相关论文
共 50 条
  • [41] Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats
    Tian, Dai-shi
    Xie, Min-jie
    Yu, Zhi-yuan
    Zhang, Qiang
    Wang, Yi-hui
    Chen, Bin
    Chen, Chen
    Wang, Wei
    BRAIN RESEARCH, 2007, 1135 (01) : 177 - 185
  • [42] Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death
    Michikawa, M
    Yanagisawa, K
    JOURNAL OF NEUROCHEMISTRY, 1999, 72 (06) : 2278 - 2285
  • [43] Inhibition of staurosporine-induced neuronal cell death by bisphenol A and nonylphenol in primary cultured rat hippocampal and cortical neurons
    Negishi, T
    Ishii, Y
    Kyuwa, S
    Kuroda, Y
    Yoshikawa, Y
    NEUROSCIENCE LETTERS, 2003, 353 (02) : 99 - 102
  • [44] Inhibition of IκBα phosphorylation prevents glutamate-induced NF-κB activation and neuronal cell death
    Pizzi, M
    Sarnico, I
    Boroni, F
    Benetti, A
    Benarese, M
    Spano, PF
    RE-ENGINEERING OF THE DAMAGED BRAIN AND SPINAL CORD: EVIDENCE-BASED NEUROREHABILITATION, 2005, 93 : 59 - 63
  • [45] Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-β-induced neuronal cell death
    Noh, Min-Young
    Koh, Seong-Ho
    Kim, Youngchul
    Kim, Hyun Young
    Cho, Goang Won
    Kim, Seung Hyun
    JOURNAL OF NEUROCHEMISTRY, 2009, 108 (05) : 1116 - 1125
  • [46] Inhibition of neuronal nitric oxide synthase increases adrenalectomy-induced granule cell death in the rat dentate gyrus
    Park, C
    Kang, M
    Kim-Kwon, Y
    Kim, J
    Ahn, H
    Huh, Y
    BRAIN RESEARCH, 2002, 933 (01) : 81 - 84
  • [47] Pharmacological Inhibition of eIF2α Phosphorylation by Integrated Stress Response Inhibitor (ISRIB) Ameliorates Vascular Calcification in Rats
    Dong, Jianlong
    Jin, Sheng
    Guo, Jingjing
    Yang, Rui
    Tian, Danyang
    Xue, Hongmei
    Xiao, Lin
    Guo, Qi
    Wang, Ru
    Xu, Meng
    Teng, Xu
    Wu, Yuming
    PHYSIOLOGICAL RESEARCH, 2022, 71 (03) : 379 - 388
  • [48] Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death
    Rinaldi, Vera D.
    Hsieh, Kristin
    Munroe, Robert
    Bolcun-Filas, Ewelina
    Schimenti, John C.
    GENETICS, 2017, 206 (04) : 1823 - 1828
  • [49] Glutamate-induced neuronal cell death in cerebral infarction.
    Matsumoto, M
    JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 1996, 18 (06): : 459 - 464
  • [50] Lidocaine-induced cell death in a human model of neuronal apoptosis
    Friederich, P
    Schmitz, TP
    EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2002, 19 (08) : 564 - 570