Neuronal apoptosis and inflammatory reaction in rat models of focal cerebral ischemia following 40-minute suspended moxibustion

被引：7

作者：

Chen, Rixin ^{[1
]}

Lv, Zhimai ^{[2
]}

Chen, Mingren ^{[1
]}

An, Xin ^{[1
]}

Xie, Dingyi ^{[1
]}

Yi, Jing ^{[1
]}

机构：

[1] Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, Nanchang 330006, Jiangxi, Peoples R China

[2] Gannan Med Univ, Affiliated Hosp 1, Ganzhou 341000, Jiangxi, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 15期

基金：

中国国家自然科学基金;

关键词：

moxibustion; cerebral ischemia; caspase-3; cyclooxygenase-2; inducible nitric oxide synthase; neural regeneration; BRAIN-DAMAGE; STROKE; NEUROPROTECTION; DEFICITS; GENE;

D O I：

10.3969/j.issn.1673-5374.2011.15.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The treatment duration of heat-sensitive moxibustion (approximately 40 minutes on average) is longer than that of traditional suspended moxibustion. The present study investigated expression changes of three inflammatory and apoptosis-associated proteins (inducible nitric oxide synthase, cyclooxygenase-2 and caspase-3) in transient middle cerebral artery occlusion model rats following suspended moxibustion for 40 minutes, to explore the mechanisms underlying neuroprotective action of suspended moxibustion. The results indicated that suspended moxibustion at acupoint Dazhui (DU 14) for 40 minutes reduced the cortical expression of caspase-3, cyclooxygenase-2 and inducible nitric oxide synthase proteins of transient middle cerebral artery occlusion model rats, as well as decreasing infarct volume and ameliorating the neurological deficit score. Outcomes with 40 minutes of moxibustion were superior to the outcomes after suspended moxibustion for 15 minutes.

引用

页码：1180 / 1184

页数：5

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