The Ganglioside GD3 as the Greek goddess hecate: Several faces turned towards as many directions

被引：27
作者：
Malisan, F [1 ]
Testi, R [1 ]
机构：
[1] Univ Tor Vergata, Dept Expt Med & Biochem Sci, Lab Immunol & Signal Transduct, I-00133 Rome, Italy
来源：
IUBMB LIFE | 2005年 / 57卷 / 07期
关键词：
Gangliosides; GD3; mitochondria; apoptosis; cancer;
D O I：
10.1080/15216540500167179
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The disialoganglioside GD3 can mediate biological functions as diverse as proliferation, differentiation, and apoptosis. Since intracellular level of GD3 is crucial for the cell, understanding the mechanisms by which GD3 metabolism is tightly regulated seems of particular importance. GD3 can be enlisted among the most potent natural inducers of mitochondrial damage and apoptosis. However, some cell types resist GD3-mediated mitochondrial damage through complex mechanisms which are beginning to be unveiled.
引用
收藏
页码：477 / 482
页数：6
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