The Ganglioside GD3 as the Greek goddess hecate: Several faces turned towards as many directions

被引：27

作者：

Malisan, F ^{[1
]}

Testi, R ^{[1
]}

机构：

[1] Univ Tor Vergata, Dept Expt Med & Biochem Sci, Lab Immunol & Signal Transduct, I-00133 Rome, Italy

来源：

IUBMB LIFE | 2005年 / 57卷 / 07期

关键词：

Gangliosides; GD3; mitochondria; apoptosis; cancer;

D O I：

10.1080/15216540500167179

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The disialoganglioside GD3 can mediate biological functions as diverse as proliferation, differentiation, and apoptosis. Since intracellular level of GD3 is crucial for the cell, understanding the mechanisms by which GD3 metabolism is tightly regulated seems of particular importance. GD3 can be enlisted among the most potent natural inducers of mitochondrial damage and apoptosis. However, some cell types resist GD3-mediated mitochondrial damage through complex mechanisms which are beginning to be unveiled.

引用

页码：477 / 482

页数：6

共 45 条

[1] BHUNIA AK, 2002, J BIOL CHEM, V22, P22
[2] Role of tumor-associated gangliosides in cancer progression
Birklé, S
Zeng, G
Gao, L
Yu, RK
Aubry, J
[J]. BIOCHIMIE, 2003, 85 (3-4) : 455 - 463
[3] Activation of Fas receptor is required for the increased formation of the disialoganglioside GD3 in cultured cerebellar granule cells committed to apoptotic death
Castiglione, M
Spinsanti, P
Iacovelli, L
Lenti, L
Martini, F
Gradini, R
Gerevini, VD
Caricasole, A
Caruso, A
De Maria, R
Nicoletti, F
Melchiorri, D
[J]. NEUROSCIENCE, 2004, 126 (04) : 889 - 898
[4] Chapman Paul B, 2003, Curr Opin Investig Drugs, V4, P710
[5] A phase II trial comparing five dose levels of BEC2 anti-idiotypic monoclonal antibody vaccine that mimics GD3 ganglioside
Chapman, PB
Williams, L
Salibi, N
Hwu, WJ
Krown, SE
Livingston, PO
[J]. VACCINE, 2004, 22 (21-22) : 2904 - 2909
[6] Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation -: Possible role of ganglioside GD3
Colell, A
Morales, A
Fernández-Checa, JC
García-Ruiz, C
[J]. FEBS LETTERS, 2002, 526 (1-3) : 135 - 141
[7] Colell Anna, 2001, FASEB Journal, V15, P1068
[8] Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells
De Maria, R
Rippo, MR
Schuchman, EH
Testi, R
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (06) : 897 - 902
[9] Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis
DeMaria, R
Lenti, L
Malisan, F
dAgostino, F
Tomassini, B
Zeuner, A
Rippo, MR
Testi, R
[J]. SCIENCE, 1997, 277 (5332) : 1652 - 1655
[10] Redox regulation and signaling lipids in mitochondrial apoptosis
Fernández-Checa, JC
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 304 (03) : 471 - 479

← 1 2 3 4 5 →