An enantioselective synthesis of the Strychnos alkaloid (-)-tubifoline

被引：23

作者：

Amat, M

Coll, MD

Passarella, D

Bosch, J

机构：

[1] Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 10期

关键词：

D O I：

10.1016/0957-4166(96)00359-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An enantioselective synthesis of the Strychnos alkaloid (-)-tubifoline, involving the kinetic resolution of racemic 1-(3-pyridyl)ethanol, the orthoester Claisen rearrangement of the enantiopure allylic alcohol 5, Smith indolization of the resulting 4-piperidineacetate 6, photocyclization of chloroacetamide 9, and final transannular cyclization, is reported. Copyright (C) 1996 Elsevier Science Ltd

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页码：2775 / 2778

页数：4

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