Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

被引：143

作者：

Mao, Jiayi ^{[1
]}

Chen, Lu ^{[2
]}

Cai, Zhengwei ^{[3
]}

Qian, Shutong ^{[1
]}

Liu, Zhimo ^{[1
]}

Zhao, Binfan ^{[1
]}

Zhang, Yuguang ^{[1
]}

Sun, Xiaoming ^{[1
]}

Cui, Wenguo ^{[3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, 639 Zhi Zao Ju Rd, Shanghai 200011, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Plast & Burn Surg, 1 Youyi Rd, Chongqing 400042, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med,Ruijin Hosp, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai Inst Traumatol & Orthopaed, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2022年 / 32卷 / 12期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

biomaterials; macrophage polarization; tissue regeneration; wound healing; wound microenvironment; SULFATED HYALURONAN; FIBROUS SCAFFOLDS; BONE REGENERATION; CROSS-LINKING; IN-VITRO; HYDROGELS; M2; NANOPARTICLES; MICROENVIRONMENT; INFLAMMATION;

D O I：

10.1002/adfm.202111003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Macrophage immunotherapy is an emerging treatment strategy that modulates the immune system to promote wound healing. The functionality and regeneration of tissue depend on spatially and temporally regulating the biophysical and biochemical microenvironmental with poorly understood mechanisms. Biomaterials are carefully crafted to display and deliver macrophage regulatory signals in a precise and near-physiological way, serving as powerful artificial microenvironments in which to explore and direct the fate of macrophages. The review starts with discussing the classification and function of macrophages, and then introduces the polarization of macrophages in different microenvironments of conventional wounds and chronic wounds. Recent advances in biomaterials that balance the phenotypes of macrophages in wound healing are emphasized. Finally, looking ahead, the potential ability of biomaterial scaffolds to modulate immune signaling to produce an environment conducive to regeneration is discussed.

引用

页数：25

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