Identification and structure-activity relationship studies of osthol, a cytotoxic principle from Cnidium monnieri

被引：18

作者：

Hitotsuyanagi, Y ^{[1
]}

Kojima, H ^{[1
]}

Ikuta, H ^{[1
]}

Takeya, K ^{[1
]}

Itokawa, H ^{[1
]}

机构：

[1] TOKYO UNIV PHARM & LIFE SCI,HACHIOJI,TOKYO 19203,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 15期

关键词：

D O I：

10.1016/0960-894X(96)00315-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Osthol (1) was isolated from the fruit of Cnidium monnieri as a cytotoxic principle. Its structure-activity relationship study reveals that the 3,4-olefinic bond is essential for its cytotoxic activity, and the prenyl (C-5) unit attached at the 8 position enhances the cytotoxicity. Analogues 7 and 8 that have a longer alkoxy unit at the 7 position showed ten times higher cytotoxicity than 1. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1791 / 1794

页数：4

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