Identification and structure-activity relationship studies of osthol, a cytotoxic principle from Cnidium monnieri

被引：18
作者：
Hitotsuyanagi, Y [1 ]
Kojima, H [1 ]
Ikuta, H [1 ]
Takeya, K [1 ]
Itokawa, H [1 ]
机构：
[1] TOKYO UNIV PHARM & LIFE SCI,HACHIOJI,TOKYO 19203,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 15期
关键词：
D O I：
10.1016/0960-894X(96)00315-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Osthol (1) was isolated from the fruit of Cnidium monnieri as a cytotoxic principle. Its structure-activity relationship study reveals that the 3,4-olefinic bond is essential for its cytotoxic activity, and the prenyl (C-5) unit attached at the 8 position enhances the cytotoxicity. Analogues 7 and 8 that have a longer alkoxy unit at the 7 position showed ten times higher cytotoxicity than 1. Copyright (C) 1996 Elsevier Science Ltd
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页码：1791 / 1794
页数：4
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