Potential of nanoparticulate based delivery systems for effective management of alopecia

被引:31
作者
Mishra, Priya [1 ]
Handa, Mayank [1 ]
Ujjwal, Rewati R. [1 ]
Singh, Vanshikha [2 ]
Kesharwani, Prashant [3 ]
Shukla, Rahul [1 ]
机构
[1] Natl Inst Pharmaceut Educ & Res Raebareli, Dept Pharmaceut, Lucknow 226002, Uttar Pradesh, India
[2] Jamia Hamdard, Sch Pharmaceut Educ & Res, New Delhi 110062, India
[3] Jamia Hamdard, Dept Pharmaceut, Sch Pharmaceut Educ & Res, New Delhi 110062, India
关键词
Alopecia; Topical delivery; Hair; Minoxidil; Nanomedicine; Nanotoxicity; Preclinical; SOLID LIPID NANOPARTICLES; ENHANCED TOPICAL DELIVERY; IN-VITRO RELEASE; DERMAL DELIVERY; FOLLICULAR DELIVERY; ANDROGENETIC ALOPECIA; HAIR-FOLLICLES; PARTICLE-SIZE; CLOBETASOL PROPIONATE; TRANSFEROSOMAL GEL;
D O I
10.1016/j.colsurfb.2021.112050
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
In recent times, more than 50 % of the global population is facing hair-related issues (alopecia) which is seen mostly amongst the people in the age group of 30-40 years. The conventional topical dosage forms available in the market falls short in effectively managing alopecia. Despite various advancements in topical dosage forms, it is still disposed to limited clinical application and provides poor penetration of drug molecules into the skin. The exact etiology of alopecia is still unknown and various researchers link lifestyle, hereditary, and auto immune based events with its existence. Nanoparticulate-based delivery are hence brought in use to enhance the permeability properties of the drug. In comparison to conventional methods nanotechnology-based drug delivery system tames drug molecules to a specific site with much better efficacy. This review is engrossed in the journey and role of nano technological-based drug delivery in the management of alopecia and its clinical application.
引用
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页数:16
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