Quality Is King: Fundamental Insights into Tumor Antigenicity from Virus-Associated Merkel Cell Carcinoma

被引:6
|
作者
Lahman, Miranda C. [1 ,2 ]
Paulson, Kelly G. [1 ,2 ,3 ,4 ]
Nghiem, Paul T. [1 ,2 ]
Chapuis, Aude G. [1 ,2 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Clin Res Div, Seattle, WA 98109 USA
[2] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA
[3] Swedish Canc Inst, Med Oncol, Seattle, WA USA
[4] Washington State Univ, Elson S Floyd Coll Med, Spokane, WA USA
关键词
MHC-CLASS-I; VASCULAR E-SELECTIN; T-CELLS; INDEPENDENT PREDICTOR; DOWN-REGULATION; PD-1; BLOCKADE; ANTI-PD-L1; ANTIBODY; MUTATIONAL BURDEN; REGULATORY T; POLYOMAVIRUS;
D O I
10.1016/j.jid.2020.12.037
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Merkel cell carcinoma (MCC) is a rare skin malignancy that is a paradigm cancer for solid tumor immunotherapy. MCCs associated with Merkel cell polyomavirus (virus-positiveMCC [VP-MCC]) or chronicUV exposure (virus-negative MCC [VN-MCC]) are antiePD(L)1 responsive, despite VP-MCC's low mutational burden. This suggests that antigen quality, not merely mutation quantity, dictates immunotherapy responsiveness, and cell-based therapies targeting optimal antigens may be effective. Despite VP-MCC's antigenic homogeneity, diverse T-cell infiltration patterns are observed, implying microenvironment plasticity and multifactorial contributions to immune recognition. Moreover, VP-MCC exemplifies how antitumor adaptive immunity can provide tumor burden biomarkers for early detection and disease monitoring.
引用
收藏
页码:1897 / 1905
页数:9
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