Hepatocellular carcinoma surveillance: current practice and future directions

被引：37

作者：

Ahn, Joseph C. ^{[1
]}

Lee, Yi-Te ^{[2
,3
]}

Agopian, Vatche G. ^{[4
,5
]}

Zhu, Yazhen ^{[2
,3
]}

You, Sungyong ^{[6
,7
]}

Tseng, Hsian-Rong ^{[2
,3
]}

Yang, Ju Dong ^{[6
,8
,9
]}

机构：

[1] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

[2] Univ Calif Los Angeles, Calif NanoSyst Inst, Crump Inst Mol Imaging, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90048 USA

[6] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA

[7] Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA 90048 USA

[8] Cedars Sinai Med Ctr, Karsh Div Gastroenterol & Hepatol, 8900 Beverly Blvd, Los Angeles, CA 90048 USA

[9] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Los Angeles, CA 90048 USA

来源：

HEPATOMA RESEARCH | 2022年 / 8卷

基金：

美国国家卫生研究院;

关键词：

Hepatocellular carcinoma; surveillance; cirrhosis; hepatitis B virus; alpha-fetoprotein; liquid biopsy; under-utilization; RANDOMIZED CONTROLLED-TRIAL; CONTRAST-ENHANCED ULTRASONOGRAPHY; CIRCULATING TUMOR-CELLS; CHRONIC LIVER-DISEASE; CHRONIC HEPATITIS-B; ALPHA-FETOPROTEIN; CANCER; ULTRASOUND; RISK; GUIDELINES;

D O I：

10.20517/2394-5079.2021.131

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is among the leading causes of cancer incidence and mortality worldwide. Surveillance of individuals with cirrhosis or other conditions that confer a high risk of HCC development is essential for early detection and improved overall survival. Biannual ultrasonography with or without alpha-fetoprotein is widely recommended as the standard method for HCC surveillance, but it has limited sensitivity in early disease and may be inadequate in certain individuals. This review article will provide a comprehensive overview of the current landscape of HCC surveillance, including the rationale and indications for HCC surveillance, standard methods for HCC surveillance, and their strengths/limitations. Alternative surveillance methods such as the role of cross-sectional imaging, emerging circulating biomarkers, as well as the problem of under-utilization of HCC surveillance and surveillance-related harms will also be discussed in this review.

引用

页数：12

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