Bioactive modulators targeting STING adaptor in cGAS-STING pathway

被引：41
|
作者：
Feng, Xi [1 ]
Liu, Dongyu [1 ]
Li, Zhiyu [1 ]
Bian, Jinlei [1 ]
机构：
[1] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R China
来源：
DRUG DISCOVERY TODAY | 2020年 / 25卷 / 01期
基金：
中国国家自然科学基金;
关键词：
INNATE; ACTIVATION; SENSOR; DESIGN;
D O I：
10.1016/j.drudis.2019.11.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-pathway triggers innate immune responses by recognizing cytosolic DNA. Recent studies revealed that STING adaptor associates with various diseases, and several modulators targeting STING have been identified including three agonists that have entered clinical trials for treating cancer over the past 2 years. In particular, the efficacy of STING agonists and/or antagonists suggests adaptor STING as a potential therapeutic target for diverse diseases. Herein, we summarize the latest advances in understanding STING functioning and provide an overview of recent STING modulator discoveries, including structural details and the potential therapeutic applications of these modulators.
引用
收藏
页码：230 / 237
页数：8
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