Using multi-omics methods to understand dermatomyositis/polymyositis

被引：43
|
作者：
Gao, Siming [1 ]
Luo, Hui [1 ]
Zhang, Huali [2 ]
Zuo, Xiaoxia [1 ]
Wang, Li [2 ]
Zhu, Honglin [1 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Dept Rheumatol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, 110 Xiangya Rd, Changsha 410008, Hunan, Peoples R China
来源：
AUTOIMMUNITY REVIEWS | 2017年 / 16卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Dermatomyositis; Polymyositis; Pathogenesis; Multi-omics; IDIOPATHIC INFLAMMATORY MYOPATHY; SIGNAL RECOGNITION PARTICLE; INDUCIBLE GENE-EXPRESSION; INTERSTITIAL LUNG-DISEASE; GENOME-WIDE ASSOCIATION; TRANSFER-RNA-SYNTHETASE; DISTINCT HLA-A; PROTECTIVE FACTORS; ALLELIC PROFILES; MYOSITIS AUTOANTIBODIES;
D O I：
10.1016/j.autrev.2017.07.021
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Idiopathic inflammatory myopathies (IIM) are a group of rare and heterogeneous autoimmune diseases, and the most common subtypes are dermatomyositis (DM) and polymyositis (PM). Despite extensive efforts, the underlying mechanism of IIM remains unclear. Recent efforts to understand the pathogenesis of IIM have included genomics, epigenetics, transcriptomics, proteomics and autoantibody studies. This review focuses on recent studies in DM/PM research based on multi-omics. This integrated analysis of multi-omics profiling will provide useful in-sights into DM/PM pathogenesis and recommendations for therapeutic targets and biomarkers development (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：1044 / 1048
页数：5
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