Macrophage diversity in cancer revisited in the era of single-cell omics

被引：363

作者：

Ma, Ruo-Yu ^{[1
]}

Black, Annabel ^{[2
]}

Qian, Bin-Zhi ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Human Phenome Inst, Zhangjiang Fudan Int Innovat Ctr, Shanghai, Peoples R China

[2] Univ Edinburgh, Inst Genet & Mol Med, Edinburgh Canc Res UK Ctr, Edinburgh, Scotland

[3] Univ Edinburgh, Queens Med Res Inst, Coll Med & Vet Med, MRC Ctr Reprod Hlth, Edinburgh, Scotland

来源：

TRENDS IN IMMUNOLOGY | 2022年 / 43卷 / 07期

基金：

英国医学研究理事会; 欧洲研究理事会; 中国博士后科学基金;

关键词：

TUMOR-ASSOCIATED MACROPHAGES; TISSUE-RESIDENT MACROPHAGES; IMMUNE CELLS; REVEALS; MICROENVIRONMENT; LANDSCAPE; MONOCYTES; METASTASIS; ONTOGENY; RECEPTOR;

D O I：

10.1016/j.it.2022.04.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor-associated macrophages (TAMs) have multiple potent functions in can-cer and, thus, represent important therapeutic targets. These diverse functions highlight the heterogenous nature of TAMs. Recent single cell omics technolo-gies have significantly advanced our understanding of the molecular diversity of TAMs. However, a unifying nomenclature of TAM diversity and annotation of their molecular signatures is lacking. Here, we review recent major studies of single cell transcriptome, epigenome, metabolome, and spatial omics of cancer with a specific focus on TAMs. We also propose a consensus model of TAM diversity and present avenues for future research.

引用

页码：546 / 563

页数：18

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