New potential drug leads against MDR-MTB: A short review

被引：20
作者：
Gatadi, Srikanth [1 ]
Nanduri, Srinivas [1 ]
机构：
[1] NIPER, Dept Med Chem, Hyderabad 500037, India
来源：
BIOORGANIC CHEMISTRY | 2020年 / 95卷
关键词：
Drug resistance; Multidrug resistant Mycobacterium tuberculosis (MDR-MTB); In vitro activity; Structure Activity Relationship (SAR); MYCOBACTERIUM-TUBERCULOSIS ACTIVITY; IN-VITRO ACTIVITY; BIOLOGICAL EVALUATION; ANTIMYCOBACTERIAL ACTIVITY; ANTITUBERCULOSIS ACTIVITY; ANTIMICROBIAL RESISTANCE; GLUTAMINE-SYNTHETASE; CRYSTAL-STRUCTURES; DELIVERY SYSTEMS; DERIVATIVES;
D O I：
10.1016/j.bioorg.2019.103534
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Multidrug resistant Mycobacterium tuberculosis (MDR-MTB) infections have created a critical health problem globally. The appalling rise in drug resistance to all the current therapeutics has triggered the need for identifying new antimycobacterial agents effective against multidrug-resistant Mycobacterium tuberculosis. Structurally unique chemical entities with new mode of action will be required to combat this pressing issue. This review gives an overview of the structures and outlines on various aspects of in vitro pharmacological activities of new antimycobacterial agents, mechanism of action and brief structure activity relationships in the perspective of drug discovery and development. This review also summarizes on recent reports of new antimycobacterial agents.
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页数：17
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