Three polymorphisms in interleukin-1β gene and risk for breast cancer: a meta-analysis

被引：32

作者：

Liu, Xiaoan ^{[1
]}

Wang, Zhanwei ^{[2
]}

Yu, Jinhua ^{[3
]}

Lei, Gang ^{[3
]}

Wang, Shui ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Breast Surg, Nanjing 210029, Peoples R China

[2] Nanjing Med Univ, Dept Epidemiol & Biostat, Nanjing 210029, Peoples R China

[3] Nanjing Med Univ, Sch Stomatol, Dent Res Inst, Nanjing 210029, Peoples R China

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2010年 / 124卷 / 03期

关键词：

Interleukin-1; beta; Polymorphism; Breast cancer; Meta-analysis; INFLAMMATORY CYTOKINES; DISEASE; IL-1B; WOMEN; CELLS;

D O I：

10.1007/s10549-010-0910-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin-1 beta (IL-1 beta), which is involved in inflammatory and immunological responses, plays an important role in the development and progression of breast cancer. Three functional single nucleotide polymorphisms (SNPs) identified in IL-1 beta gene are thought to influence breast cancer risk. The results of the association between IL-1 beta polymorphisms and breast cancer remain inconsistent. Therefore, we conducted a meta-analysis of eight case control studies with rs1143627 (T > C), rs16944 (C > T), and rs1143634 (C > T). We found that the variant CC genotype of rs1143627 was associated with a significantly increased breast cancer risk (CC vs. TT: OR = 1.37, 95% CI = 1.10-1.70, P = 0.22 for heterogeneity; the recessive model CC vs. TT/TC: OR = 1.40, 95% CI = 1.17-1.67, P = 0.49 for heterogeneity). For rs16944 (C > T) and rs1143634 (C > T), no significant associations were found in all genetic models. In conclusion, the present meta-analysis suggests that rs1143627 is associated with breast cancer risk.

引用

页码：821 / 825

页数：5

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