Analgesic and anti-inflammatory activity of the leaf essential oil of Laurus nobilis Linn.

被引：77
作者：
Sayyah, M
Saroukhani, G
Peirovi, A
Kamalinejad, M
机构：
[1] Inst Pasteur Iran, Dept Physiol & Pharmacol, Tehran 13164, Iran
[2] Shaheed Beheshti Univ Med Sci, Fac Pharm, Dept Pharmacognosy, Tehran, Iran
来源：
PHYTOTHERAPY RESEARCH | 2003年 / 17卷 / 07期
关键词：
analgesic; anti-inflammatory effect; essential oil; Laurus nobilis Linn;
D O I：
10.1002/ptr.1197
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The leaf essential oil of Laurus nobilis Linn. (Lauraceae) has been evaluated for antinociceptive and anti-inflammatory activities in mice and rats. The essential oil exhibited: (1) a significant analgesic effect in tail-flick and formalin tests; (2) a dose-dependent anti-inflammatory effect in the formalin-induced edema and (3) a moderate sedative effect at the anti-inflammatory doses. The analgesic and anti-inflammatory effect of the essential oil was comparable to reference analgesics and non-steroid anti-inflammatory drugs: morphine and piroxicam. Present results make the essential oil worthy of further investigations. Copyright (C) 2003 John Wiley Sons, Ltd.
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页码：733 / 736
页数：4
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