In Vitro Antifungal Activities of Isavuconazole and Comparators against Rare Yeast Pathogens

被引：25
作者：
Guinea, Jesus [1 ,2 ,3 ]
Recio, Sandra
Escribano, Pilar
Pelaez, Teresa [2 ,3 ]
Gama, Beatriz
Bouza, Emilio [2 ,3 ]
机构：
[1] Univ Complutense Madrid, Clin Microbiol & Infect Dis Dept, Hosp Gen Univ Gregorio Maranon, Serv Microbiol Clin & Enfermedades Infecciosas VI, Madrid 28007, Spain
[2] CIBER Enfermedades Resp CIBER RES CD06 06 0058, Palma de Mallorca, Spain
[3] Univ Complutense Madrid, Dept Microbiol, Sch Med, Madrid 28007, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 09期
关键词：
CRYPTOCOCCUS-NEOFORMANS; ASPERGILLUS-FUMIGATUS; FUNGAL PATHOGENS; VORICONAZOLE; CANDIDA; ITRACONAZOLE; TRICHOSPORON; FLUCONAZOLE; RHODOTORULA; GEOTRICHUM;
D O I：
10.1128/AAC.00685-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We compared the in vitro activities of isavuconazole, posaconazole, voriconazole, and fluconazole against Dipodascus capitatus (n = 21), Saccharomyces cerevisiae ( n = 20), Rhodotorula mucilaginosa ( n = 18), and Trichosporon spp. (n = 15). The MIC(50)s, MIC(90)s, and MIC ranges ( in mu g/ml) obtained using the CLSI M27-A3 procedure were as follows: isavuconazole, 0.125, 0.5, and <= 0.015 to 2; posaconazole, 0.5, 2, and <= 0.015 to >16; voriconazole, 0.125, 2, and <= 0.015 to 8; and fluconazole, 4, >128, and <= 0.125 to >128. Isavuconazole showed potent activity against the isolates studied.
引用
收藏
页码：4012 / 4015
页数：4
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