Gut Check: Clostridium difficile Testing and Treatment in the Molecular Testing Era

被引：42

作者：

Buckel, Whitney R. ^{[1
]}

Avdic, Edina ^{[2
]}

Carroll, Karen C. ^{[3
,4
]}

Gunaseelan, Vidhya ^{[2
]}

Hadhazy, Eric ^{[3
]}

Cosgrove, Sara E. ^{[3
]}

机构：

[1] Intermt Healthcare, Intermt Med Ctr, Murray, UT 84107 USA

[2] Johns Hopkins Univ Hosp, Johns Hopkins Hlth Syst, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Pathol, Div Med Microbiol, Baltimore, MD 21205 USA

来源：

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2015年 / 36卷 / 02期

关键词：

RISK-FACTORS; INFECTION; COLONIZATION; PREVALENCE; IMPACT;

D O I：

10.1017/ice.2014.19

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We evaluated the impact of nursing education and stewardship interventions on Clostridium difficile testing and treatment appropriateness. Diarrhea documentation increased for those with positive tests (45% to 70%); pretreatment laxative use decreased (50% to 19%). Appropriate treatment increased for severe infection (57% to 93%), but all asymptomatically colonized patients were treated.

引用

页码：217 / 221

页数：5

共 10 条

[1] Prevalence and Risk Factors for Asymptomatic Clostridium difficile Carriage [J].

Alasmari, Faisal ;

Seiler, Sondra M. ;

Hink, Tiffany ;

Burnham, Carey-Ann D. ;

Dubberke, Erik R. .

CLINICAL INFECTIOUS DISEASES, 2014, 59 (02) :216-222

[2] Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) [J].

Cohen, Stuart H. ;

Gerding, Dale N. ;

Johnson, Stuart ;

Kelly, Ciaran P. ;

Loo, Vivian G. ;

McDonald, L. Clifford ;

Pepin, Jacques ;

Wilcox, Mark H. .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2010, 31 (05) :431-455

[3] Impact of Clinical Symptoms on Interpretation of Diagnostic Assays for Clostridium difficile Infections [J].

Dubberke, Erik R. ;

Han, Zhuolin ;

Bobo, Linda ;

Hink, Tiffany ;

Lawrence, Brenda ;

Copper, Susan ;

Hoppe-Bauer, Joan ;

Burnham, Carey-Ann D. ;

Dunne, William Michael, Jr. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (08) :2887-2893

[4] Assessment of treatment patterns and patient outcomes before vs after implementation of a severity-based Clostridium difficile infection treatment policy [J].

Jardin, C. G. M. ;

Palmer, H. R. ;

Shah, D. N. ;

Le, F. ;

Beyda, N. D. ;

Jiang, Z. ;

Garey, K. W. .

JOURNAL OF HOSPITAL INFECTION, 2013, 85 (01) :28-32

[5] TREATMENT OF ASYMPTOMATIC CLOSTRIDIUM-DIFFICILE CARRIERS (FECAL EXCRETORS) WITH VANCOMYCIN OR METRONIDAZOLE - A RANDOMIZED, PLACEBO-CONTROLLED TRIAL [J].

JOHNSON, S ;

HOMANN, SR ;

BETTIN, KM ;

QUICK, JN ;

CLABOTS, CR ;

PETERSON, LR ;

GERDING, DN .

ANNALS OF INTERNAL MEDICINE, 1992, 117 (04) :297-302

[6] Asymptomatic Clostridium difficile colonization in a tertiary care hospital: Admission prevalence and risk factors [J].

Leekha, Surbhi ;

Aronhalt, Kimberly C. ;

Sloan, Lynne M. ;

Patel, Robin ;

Orenstein, Robert .

AMERICAN JOURNAL OF INFECTION CONTROL, 2013, 41 (05) :390-393

[7] Impact of the Type of Diagnostic Assay on Clostridium difficile Infection and Complication Rates in a Mandatory Reporting Program [J].

Longtin, Yves ;

Trottier, Sylvie ;

Brochu, Gilles ;

Paquet-Bolduc, Bianka ;

Garenc, Christophe ;

Loungnarath, Vilayvong ;

Beaulieu, Catherine ;

Goulet, Danielle ;

Longtin, Jean .

CLINICAL INFECTIOUS DISEASES, 2013, 56 (01) :67-73

[8] Host and Pathogen Factors for Clostridium difficile Infection and Colonization [J].

Loo, Vivian G. ;

Bourgault, Anne-Marie ;

Poirier, Louise ;

Lamothe, Francois ;

Michaud, Sophie ;

Turgeon, Nathalie ;

Toye, Baldwin ;

Beaudoin, Axelle ;

Frost, Eric H. ;

Gilca, Rodica ;

Brassard, Paul ;

Dendukuri, Nandini ;

Beliveau, Claire ;

Oughton, Matthew ;

Brukner, Ivan ;

Dascal, Andre .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (18) :1693-1703

[9] Detection of toxigenic clostridium difficile in stool samples by real-time polymerase chain reaction for the diagnosis of C-difficile -: Associated diarrhea [J].

Peterson, Lance R. ;

Manson, Rebecca U. ;

Paule, Suzanne M. ;

Hacek, Donna M. ;

Robicsek, Ari ;

Thomson, Richard B. ;

Kaul, Karen L. .

CLINICAL INFECTIOUS DISEASES, 2007, 45 (09) :1152-1160

[10] Antimicrobial Prescribing Practices in Response to Different Clostridium difficile Diagnostic Methodologies [J].

Sydnor, Emily R. M. ;

Lenhart, Abigail ;

Trollinger, Brandon ;

Avdic, Edina ;

Maragakis, Lisa L. ;

Carroll, Karen C. ;

Cosgrove, Sara E. .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2011, 32 (11) :1133-1136

← 1 →