Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy

被引：8

作者：

Ksouda, Kamilia ^{[1
]}

Affes, Hanen ^{[1
]}

Atheymen, Rim ^{[1
]}

Ezzeddine, Mariem ^{[2
]}

Zeghal, Khaled ^{[1
]}

Hammami, Serria ^{[1
]}

机构：

[1] CHU Hedi Chaker Sfax, Sch Med Sfax, Dept Pharmacol, Sfax, Tunisia

[2] CHU Hedi Chaker Sfax, Dept Rheumatol, Sfax, Tunisia

来源：

INDIAN JOURNAL OF PHARMACOLOGY | 2014年 / 46卷 / 06期

关键词：

Autoimmune hepatitis; drug-induced autoimmunity; methotrexate; psoriatic arthritis;

D O I：

10.4103/0253-7613.144940

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Methotrexate (MTX) is one of the most commonly used medicines in the treatment of psoriatic arthritis. The drug can produce steatosis and cirrhosis. Autoimmune hepatitis is a rare and serious adverse effect. We describe the case of a 53-year-old woman who developed autoimmune hepatitis after a long-term use of MTX for psoriatic arthritis. Hepatitis was completely resolved 4 months after stopping this drug. The pathophysiologic mechanisms of a drug-induced autoimmunity are unclear and complex. This report confirms the need to monitor liver enzymes carefully in patients using long-term treatment with MTX for psoriasis or rheumatoid arthritis.

引用

页码：649 / 650

页数：2

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