The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases

被引：356

作者：

Balistreri, Carmela Rita ^{[1
]}

Caruso, Calogero ^{[1
]}

Candore, Giuseppina ^{[1
]}

机构：

[1] Univ Palermo, Dept Pathobiol & Med & Forens Biotechnol, Immunosenescence Grp, I-90134 Palermo, Italy

来源：

MEDIATORS OF INFLAMMATION | 2010年 / 2010卷

关键词：

BODY-MASS INDEX; NECROSIS-FACTOR-ALPHA; TYPE-2; DIABETIC-PATIENTS; NERVOUS-SYSTEM CONTROL; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; ALZHEIMER-DISEASE; PROSTATE-CANCER; KAPPA-B; IMMUNE-RESPONSE;

D O I：

10.1155/2010/802078

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune cells. As consequence, increased circulating levels of proinflammatory cytokines, hormone-like molecules, and other inflammatory markers are induced. This determines a chronic active inflammatory condition, associated with the development of the obesity-related inflammatory diseases. This paper describes the role of adipose tissue and the biological effects of many adipokines in these diseases.

引用

页数：19

共 187 条

[1] General and abdominal obesity and survival among young women with breast cancer [J].

Abrahamson, Page E. ;

Gammon, Marilie D. ;

Lund, Mary Jo ;

Flagg, Elaine W. ;

Porter, Peggy L. ;

Stevens, June ;

Swanson, Christine A. ;

Brinton, Louise A. ;

Eley, J. William ;

Coates, Ralph J. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (10) :1871-1877

[2] Revisiting leptin's role in obesity and weight loss [J].

Ahima, Rexford S. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (07) :2380-2383

[3] The metabolic syndrome - a new worldwide definition [J].

Alberti, KGMM ;

Zimmet, P ;

Shaw, J .

LANCET, 2005, 366 (9491) :1059-1062

[4] Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin-regulated aminopeptidase [J].

Albiston, AL ;

McDowall, SG ;

Matsacos, D ;

Sim, P ;

Clune, E ;

Mustafa, T ;

Lee, J ;

Mendelsohn, FAO ;

Simpson, RJ ;

Connolly, LM ;

Chai, SY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (52) :48623-48626

[5] IL6 as a mediator of insulin resistance: fat or fiction? [J].

Allen, T. L. ;

Febbraio, M. A. .

DIABETOLOGIA, 2010, 53 (03) :399-402

[6]

[Anonymous], 2006, COMPUT SCI ENG, V8, P4

[7] Effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin [J].

Araki, Takahiro ;

Emoto, Masanori ;

Teramura, Megumi ;

Yokoyama, Hisayo ;

Mori, Katsuhito ;

Hatsuda, Sawako ;

Maeno, Takaaki ;

Shinohara, Kayo ;

Koyama, Hidenori ;

Shoji, Tetsuo ;

Inaba, Masaaki ;

Nishizawa, Yoshiki .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2006, 55 (08) :996-1001

[8] Comparison of serum high-molecular weight (HMS adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin [J].

Aso, Yoshimasa ;

Yamamoto, Ruriko ;

Wakabayashi, Sadao ;

Uchida, Toshihiko ;

Takayanagi, Kan ;

Takebayashi, Kohzo ;

Okuno, Takehiko ;

Inoue, Teruo ;

Node, Koichi ;

Tobe, Takashi ;

Inukai, Toshihiko ;

Nakano, Yasuko .

DIABETES, 2006, 55 (07) :1954-1960

[9] Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression [J].

Atluri, Pavan ;

Morine, Kevin J. ;

Liao, George P. ;

Panlilio, Corinna M. ;

Berry, Mark F. ;

Hsu, Vivian M. ;

Hiesinger, William ;

Cohen, Jeffrey E. ;

Woo, Y. Joseph .

CELLULAR & MOLECULAR BIOLOGY LETTERS, 2007, 12 (01) :127-138

[10] Adiposity and mortality in men [J].

Baik, I ;

Ascherio, A ;

Rimm, EB ;

Giovannucci, E ;

Spiegelman, D ;

Stampfer, MJ ;

Willett, WC .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2000, 152 (03) :264-271

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