Roxithromycin induced torsade de pointes in a patient with complex congenital atrioventricular block

被引：10

作者：

Promphan, W

Khongphatthanayothin, A

Horchaiprasit, K

Benjacholamas, V

机构：

[1] Chulalongkorn Univ, Dept Pediat, Div Pediat Cardiol, Bangkok, Thailand

[2] Chulalongkorn Univ, Dept Surg, Div Cardiothorac Surg, Bangkok, Thailand

[3] King Chulalongkorn Mem Hosp, Bangkok, Thailand

[4] Chonburi Hosp, Dept Pediat, Chonburi, Thailand

来源：

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY | 2003年 / 26卷 / 06期

关键词：

prolonged QT interval; torsade de pointes; roxithromycin;

D O I：

10.1046/j.1460-9592.2003.t01-1-00204.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We reported a 6-year-old girl who developed torsade de pointes (TdP) after taking roxithromycin. The patient had congenital complete heart block and complex cyanotic heart disease. Before taking roxithromycin, her corrected QT interval (QTc) was 0.39 second with a ventricular rate of 55-60 beats/min. Repetitive bursts of TdP with prolonged QT interval (QTc = 0.55 s) developed after taking roxithromycin. After stopping the medication, her QT interval normalized (QTc = 0.38 s). This case demonstrated the potential of roxithromycin in causing TdP especially in a patient with other risk factors for prolong QT interval and TdP.

引用

页码：1424 / 1426

页数：3

共 4 条

[1] A METHOD FOR ESTIMATING THE PROBABILITY OF ADVERSE DRUG-REACTIONS [J].