Research on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives

A carboxyl-terminated fullerene pyrrolidine derivative was synthesized by 1, 3-dipolar cycloaddition of imine ylide (FPCOOH). UV-Vis, FT-IR and MALDI-TOF respectively verified the effective synthesis of compounds. The compound (FPCOOH) was used as an intermediate, and then the hydrothermal chemical bonding method was used to load ferric oxide on the compound (FP-COOH). Its purpose was to form a magnetic targeting carrier system (FP-IONP-COOH). Then use the non-covalent method to combine FP-IONP-COOH with doxorubicin. The ultimate goal was to improve the side effects of doxorubicin. The solubility experiments showed that both FP-IONP-COOH and FP-IONP-COOH/DOX had good water solubility. The investigation of magnetism showed that FP-IONP-COOH has good magnetism. Finally, in vitro release experiments further verified the targeting of FP-IONP-COOH/DOX. The cumulative release of DOX at 48 h could be as high as 82 %, whereas the accumulated release of FP-IONP-COOH/DOX at 48 h was only 48 %, and was able to release for more than 120 h, its sustained release in vivo.