Is magnesium sulfate by the intrathecal route efficient and safe?

被引：17

作者：

Mebazaa, M. S. ^{[1
]}

Ouerghi, S. ^{[2
]}

Frikha, N. ^{[1
]}

Moncer, K. ^{[1
]}

Mestiri, T. ^{[2
]}

James, M. F. ^{[3
]}

Ben Ammar, M. S. ^{[1
]}

机构：

[1] Univ Hosp Mongi Slim, Dept Anesthesiol Intens Care & Emergency Med, La Marsa 2046, Sidi Daoud, Tunisia

[2] Abderrahmen Mami Hosp, Dept Thorac Surg, Ariana, Tunisia

[3] Univ Cape Town, Groote Schuur Hosp, Dept Anaesthesia, ZA-7925 Cape Town, South Africa

来源：

ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION | 2011年 / 30卷 / 01期

关键词：

Intrathecal; Magnesium; Adjuvant; Surgery; Morphine; SPINAL-ANESTHESIA; POSTOPERATIVE ANALGESIA; REQUIREMENTS; REMIFENTANIL; FENTANYL; INJURY; BRAIN; INFUSION; SURGERY; VIEW;

D O I：

10.1016/j.annfar.2010.12.005

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The polypharmacological approach to the treatment of postoperative pain has become routine in an attempt to minimize the adverse side effects of opioids. Magnesium sulphate is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and thus can modify nociceptive modulation. Intravenous administration of magnesium sulphate can improve postoperative analgesia and decrease the requirement for postoperative opiates, but the effects are inconsistent and have not been reliably accompanied by a reduction in the incidence of morphine-related adverse events. Several studies have shown that the administration of magnesium by the intrathecal route is safe and, in combination with opiates, extends the effect of spinal anaesthesia in both animal and human studies. The analysis of these studies justifies further investigation of the use of magnesium sulphate by the intrathecal route. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：47 / 50

页数：4

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