Is magnesium sulfate by the intrathecal route efficient and safe?

被引：17
作者：
Mebazaa, M. S. [1 ]
Ouerghi, S. [2 ]
Frikha, N. [1 ]
Moncer, K. [1 ]
Mestiri, T. [2 ]
James, M. F. [3 ]
Ben Ammar, M. S. [1 ]
机构：
[1] Univ Hosp Mongi Slim, Dept Anesthesiol Intens Care & Emergency Med, La Marsa 2046, Sidi Daoud, Tunisia
[2] Abderrahmen Mami Hosp, Dept Thorac Surg, Ariana, Tunisia
[3] Univ Cape Town, Groote Schuur Hosp, Dept Anaesthesia, ZA-7925 Cape Town, South Africa
来源：
ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION | 2011年 / 30卷 / 01期
关键词：
Intrathecal; Magnesium; Adjuvant; Surgery; Morphine; SPINAL-ANESTHESIA; POSTOPERATIVE ANALGESIA; REQUIREMENTS; REMIFENTANIL; FENTANYL; INJURY; BRAIN; INFUSION; SURGERY; VIEW;
D O I：
10.1016/j.annfar.2010.12.005
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
The polypharmacological approach to the treatment of postoperative pain has become routine in an attempt to minimize the adverse side effects of opioids. Magnesium sulphate is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and thus can modify nociceptive modulation. Intravenous administration of magnesium sulphate can improve postoperative analgesia and decrease the requirement for postoperative opiates, but the effects are inconsistent and have not been reliably accompanied by a reduction in the incidence of morphine-related adverse events. Several studies have shown that the administration of magnesium by the intrathecal route is safe and, in combination with opiates, extends the effect of spinal anaesthesia in both animal and human studies. The analysis of these studies justifies further investigation of the use of magnesium sulphate by the intrathecal route. (C) 2010 Elsevier Masson SAS. All rights reserved.
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收藏
页码：47 / 50
页数：4
相关论文
共 44 条
[1]   Combined intrathecal and epidural magnesium sulfate supplementation of spinal anesthesia to reduce post-operative analgesic requirements:: a prospective, randomized, double-blind, controlled trial in patients undergoing major orthopedic surgery [J].
Arcioni, R. ;
Palmisani, S. ;
Tigano, S. ;
Santorsola, C. ;
Sauli, V. ;
Romano, S. ;
Mercieri, M. ;
Masciangelo, R. ;
De Blasi, R. A. ;
Pinto, G. .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2007, 51 (04) :482-489
[2]  
Bahar M, 1996, ANAESTHESIA, V51, P627, DOI 10.1111/j.1365-2044.1996.tb07843.x
[3]  
Benhaj Amor Mondher, 2008, Tunis Med, V86, P550
[4]   Epidural magnesium reduces postoperative analgesic requirement [J].
Bilir, A. ;
Gulec, S. ;
Erkan, A. ;
Ozcelik, A. .
BRITISH JOURNAL OF ANAESTHESIA, 2007, 98 (04) :519-523
[5]   Intrathecal magnesium prolongs fentanyl analgesia: A prospective, randomized, controlled trial [J].
Buvanendran, A ;
McCarthy, RJ ;
Kroin, JS ;
Leong, W ;
Perry, P ;
Tuman, KJ .
ANESTHESIA AND ANALGESIA, 2002, 95 (03) :661-666
[6]   Neurotoxicity after spinal anaesthesia induced by serial intrathecal injections of magnesium sulphate - An experimental study in a rat model [J].
Chanimov, M ;
Cohen, ML ;
Grinspun, Y ;
Herbert, M ;
Reif, R ;
Kaufman, I ;
Bahar, M .
ANAESTHESIA, 1997, 52 (03) :223-228
[7]   Intravenous magnesium sulfate administration reduces propofol infusion requirements during maintenance of propofol-N2O anesthesia -: Part II:: Comparing propofol requirements according to hemodynamic responses [J].
Choi, JC ;
Yoon, KB ;
Um, DJ ;
Kim, C ;
Kim, JS ;
Lee, SG .
ANESTHESIOLOGY, 2002, 97 (05) :1137-1141
[8]   Intravenous magnesium sulfate for post-operative pain in patients undergoing lower limb orthopedic surgery [J].
Dabbagh, A. ;
Elyasi, H. ;
Razavi, S. S. ;
Fathi, M. ;
Rajaei, S. .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2009, 53 (08) :1088-1091
[9]   Magnesium sulfate therapy in patients with acute neuronal damage: The problem of intravenous administration [J].
Dohi, K ;
Ohtaki, H ;
Shioda, S ;
Aruga, T .
CRITICAL CARE MEDICINE, 2005, 33 (03) :698-699
[10]   The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine:: a review [J].
Dubé, L ;
Granry, JC .
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 2003, 50 (07) :732-746
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