Role of Lipid Transfer Proteins (LTPs) in the Viral Life Cycle

被引:10
作者
Avula, Kiran [1 ,2 ]
Singh, Bharati [1 ,3 ]
Kumar, Preethy, V [1 ,3 ]
Syed, Gulam H. [1 ]
机构
[1] Inst Life Sci, Virus Host Interact Lab, Bhubaneswar, India
[2] Reg Ctr Biotechnol, Faridabad, India
[3] Kalinga Inst Ind Technol, Sch Biotechnol, Bhubaneswar, India
基金
英国惠康基金;
关键词
lipid transfer proteins; virus; replication; HCV; membrane contact sites; OSBP; CERT; NPC1; HEPATITIS-C VIRUS; OXYSTEROL-BINDING-PROTEIN; NIEMANN-PICK C1; HERPES-SIMPLEX-VIRUS; GLYCOLIPID TRANSFER PROTEIN; MEMBRANE CONTACT SITES; KINASE III BETA; DENGUE VIRUS; ENDOPLASMIC-RETICULUM; STRUCTURAL BASIS;
D O I
10.3389/fmicb.2021.673509
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Viruses are obligate parasites that depend on the host cell machinery for their replication and dissemination. Cellular lipids play a central role in multiple stages of the viral life cycle such as entry, replication, morphogenesis, and egress. Most viruses reorganize the host cell membranes for the establishment of viral replication complex. These specialized structures allow the segregation of replicating viral RNA from ribosomes and protect it from host nucleases. They also facilitate localized enrichment of cellular components required for viral replication and assembly. The specific composition of the lipid membrane governs its ability to form negative or positive curvature and possess a rigid or flexible form, which is crucial for membrane rearrangement and establishment of viral replication complexes. In this review, we highlight how different viruses manipulate host lipid transfer proteins and harness their functions to enrich different membrane compartments with specific lipids in order to facilitate multiple aspects of the viral life cycle.
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页数:16
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共 165 条
[1]   Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact [J].
Achleitner, G ;
Gaigg, B ;
Krasser, A ;
Kainersdorfer, E ;
Kohlwein, SD ;
Perktold, A ;
Zellnig, G ;
Daum, G .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 264 (02) :545-553
[2]   Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection [J].
Aizaki, Hideki ;
Morikawa, Kenichi ;
Fukasawa, Masayoshi ;
Hara, Hiromichi ;
Inoue, Yasushi ;
Tani, Hideki ;
Saito, Kyoko ;
Nishijima, Masahiro ;
Hanada, Kentaro ;
Matsuura, Yoshiharu ;
Lai, Michael A. C. ;
Miyamura, Tatsuo ;
Wakita, Takaji ;
Suzuki, Tetsuro .
JOURNAL OF VIROLOGY, 2008, 82 (12) :5715-5724
[3]   Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307 [J].
Albulescu, Lucian ;
Bigay, Joelle ;
Biswas, Bishyajit ;
Weber-Boyvat, Marion ;
Dorobantu, Cristina M. ;
Delang, Leen ;
van der Schaar, Hilde M. ;
Jung, Young-Sik ;
Neyts, Johan ;
Olkkonen, Vesa M. ;
van Kuppeveld, Frank J. M. ;
Strating, Jeroen R. P. M. .
ANTIVIRAL RESEARCH, 2017, 140 :37-44
[4]   Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP [J].
Albulescu, Lucian ;
Strating, Jeroen R. P. M. ;
Thibaut, Hendrik Jan ;
van der Linden, Lonneke ;
Shair, Matthew D. ;
Neyts, Johan ;
van Kuppeveld, Frank J. M. .
ANTIVIRAL RESEARCH, 2015, 117 :110-114
[5]   Give lipids a START: The StAR-related lipid transfer (START) domain in mammals [J].
Alpy, F ;
Tomasetto, C .
JOURNAL OF CELL SCIENCE, 2005, 118 (13) :2791-2801
[6]   Protein Kinase D Negatively Regulates Hepatitis C Virus Secretion through Phosphorylation of Oxysterol-binding Protein and Ceramide Transfer Protein [J].
Amako, Yutaka ;
Syed, Gulam H. ;
Siddiqui, Aleem .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (13) :11265-11274
[7]   Role of Oxysterol Binding Protein in Hepatitis C Virus infection [J].
Amako, Yutaka ;
Sarkeshik, Ali ;
Hotta, Hak ;
Yates, John, III ;
Siddiqui, Aleem .
JOURNAL OF VIROLOGY, 2009, 83 (18) :9237-9246
[8]   The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry [J].
Amini-Bavil-Olyaee, Samad ;
Choi, Youn Jung ;
Lee, Jun Han ;
Shi, Mude ;
Huang, I-Chueh ;
Farzan, Michael ;
Jung, Jae U. .
CELL HOST & MICROBE, 2013, 13 (04) :452-464
[9]   Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site [J].
Angel Cuesta-Geijo, Miguel ;
Barrado-Gil, Lucia ;
Galindo, Inmaculada ;
Munoz-Moreno, Raquel ;
Alonso, Covadonga .
VIRUSES-BASEL, 2017, 9 (06)
[10]   Essential domains of phosphatidylinositol-4 kinase III β required for enterovirus replication [J].
Arita, Minetaro .
MICROBIOLOGY AND IMMUNOLOGY, 2019, 63 (07) :285-288