Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes

被引：7
作者：
Echeverri, Marcelo [1 ]
Alvarez-Valdes, Amparo [1 ]
Navas, Francisco [1 ]
Perles, Josefina [2 ]
Sanchez-Perez, Isabel [3 ]
Quiroga, A. G. [1 ]
机构：
[1] Univ Autonoma Madrid, Inorgan Chem Dept, Madrid, Spain
[2] Univ Autonoma Madrid, Single Crystal XRD Lab, Sldl, Madrid, Spain
[3] Inst Invest Biomed Albert Sols, Madrid, Spain
来源：
ROYAL SOCIETY OPEN SCIENCE | 2018年 / 5卷 / 02期
关键词：
metallodrug-protein interaction; cytotoxicity; platinum drugs; DNA; MOLECULAR-STRUCTURE; CRYSTAL; DNA; DRUGS;
D O I：
10.1098/rsos.171340
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Three platinum complexes with cis and trans configuration cis-[Pt(TCEP)(2)Cl-2], cis-[Pt(tmTCEP)(2)Cl-2] and trans[ Pt(TCEP)(2)Cl-2], where TCEP is tris(2-carboxyethyl) phosphine, have been synthesized and fully characterized by usual techniques including single- crystal X- ray diffraction for trans-[Pt(TCEP)(2)Cl-2] and cis-[Pt(tmTCEP)(2)Cl-2]. Here, we also report on an esterification process of TCEP, which takes place in the presence of alcohols, leading to a platinum complex coordinated to an ester tmTCEP (2-methoxycarbonylethyl phosphine) ligand. The stability in solution of the three compounds and their interaction with biological models such as DNA (pBR322 and calf thymus DNA) and proteins (lysozyme and RNase) have also been studied.
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页数：12
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