Visible-Light-Mediated Radical Aryldifluoroacetylation of Alkynes with Ethyl Bromodifluoroacetate for the Synthesis of 3-Difluoroacetylated Coumarins

被引：145

作者：

Fu, Weijun ^{[1
]}

Zhu, Mei ^{[1
]}

Zou, Guanglong ^{[2
]}

Xu, Chen ^{[1
]}

Wang, Zhigiang ^{[1
]}

Ji, Baoming ^{[1
]}

机构：

[1] Luoyang Normal Univ, Coll Chem & Chem Engn, Luoyang 471022, Peoples R China

[2] Guizhou Minzu Univ, Coll Chem & Environm Sci, Guiyang 550025, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 09期

基金：

中国国家自然科学基金;

关键词：

N-ARYLACRYLAMIDES; TRIFLUOROMETHYLATION; DIFLUOROMETHYLATION; CYCLIZATION; ALKYNOATES; ARYL; DIFLUOROACETYLATION; DIFUNCTIONALIZATION; PHOSPHONATES; OXINDOLES;

D O I：

10.1021/acs.joc.5b00305

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient method for the synthesis of 3-difluoroacetylated coumarins through visible-light-promoted aryldifluoroacetylation of alkynes with ethyl bromodifluoroacetate has been developed. The reaction allows the direct formation of C-sp(2)-CF2COOEt and C-C bonds via a proposed tandem radical cyclization process.

引用

页码：4766 / 4770

页数：5

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