Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review

被引:23
作者
Kiewisz, Jolanta [1 ]
Kaczmarek, Monika M. [2 ]
Pawlowska, Anna [3 ]
Kmiec, Zbigniew [1 ]
Stompor, Tomasz [3 ]
机构
[1] Univ Warmia & Mazury, Dept Human Histol & Embryol, Fac Med Sci, Olsztyn, Poland
[2] Polish Acad Sci, Inst Anim Reprod & Food Res, Olsztyn, Poland
[3] Univ Warmia & Mazury, Dept Nephrol Hypertens & Internal Med, Fac Med Sci, Olsztyn, Poland
关键词
endothelial progenitor cells; chronic kidney diseases; cardiovascular diseases; STAGE RENAL-DISEASE; CORONARY-ARTERY-DISEASE; HEMODIALYSIS-PATIENTS; BONE-MARROW; CAROTID ATHEROSCLEROSIS; HYPERTENSIVE PATIENTS; RHEUMATOID-ARTHRITIS; NEOINTIMA FORMATION; MIGRATORY ACTIVITY; VASCULAR FUNCTION;
D O I
10.18388/abp.2016_1284
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Endothelial progenitor cells (EPCs) represent a small population of blood cells (5-40 cells/mm(3)), with an ability to differentiate into endothelial cells that form the lining of the blood vessels and contribute to postnatal angiogenesis. Abundant evidence shows that recruitment of EPCs from the bone marrow, the monocyte/macrophage lineage and the organs facilitate the endothelial regeneration and repair. Changes in the number of EPCs were observed in both, chronic kidney and cardiovascular diseases. Thus, these cells were tested for usage in diagnosis and therapy. In this paper, we review the current knowledge on the EPC biology and contribution of these cells to the kidney and cardiovascular diseases.
引用
收藏
页码:475 / 482
页数:8
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