First Therapeutic Approval for Eosinophilic Esophagitis

被引：15

作者：

Al-Horani, Rami A. ^{[1
]}

Chiles, Raquel ^{[1
]}

机构：

[1] Xavier Univ Louisiana, Coll Pharm, Div Basic Pharmaceut Sci, New Orleans, LA 70125 USA

来源：

GASTROENTEROLOGY INSIGHTS | 2022年 / 13卷 / 03期

关键词：

esophagitis; inflammation dupilumab; monoclonal antibodies; THYMIC STROMAL LYMPHOPOIETIN; PREVALENCE; DISEASE; ASSOCIATION; EXPRESSION; EOTAXIN-3; ADULTS; RISK;

D O I：

10.3390/gastroent13030024

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Eosinophilic esophagitis (EE) is a chronic, immune-mediated or antigen-mediated esophageal disease. Treatment for patients with EE can be challenging with no previously approved medications. Current management strategies follow the four D's paradigm of drugs, dietary elimination, dilation, and disease anxiety and hypervigilance therapy. On 20 May 2022, dupilumab was approved by FDA for EE. A dose of 300 mg dupilumab weekly significantly improved signs and symptoms of EE compared to placebo in a phase 3 trial. The approval of dupilumab will fulfill an unmet need for the increasing number of patients with EE.

引用

页码：238 / 244

页数：7

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