Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum scabrum

被引：18

作者：

Hu, Jiawen

Gao, Wan

Xu, Fang

Wei, Canjing

Shi, Mengjiao

Sun, Hua

Zhen, Bo

Wang, Jiajia

Ji, Tengfei ^{[1
]}

Jiang, Jiandong ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 21期

基金：

国家自然科学基金国际合作与交流项目;

关键词：

Hypericum; PPAPs; ECD; Hepatoprotective; POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES; SAMPSONII; URALUM; CORES;

D O I：

10.1016/j.bmcl.2017.09.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new polycyclic polyprenylated acylphloroglucinol derivatives (PPAPs), hyperibrins E-G (1-3), along with seven known compounds were identified from the air-dried aerial parts of Hypericum scabrum. Their structures were determined by NMR spectroscopic methods, both experimental and calculated electronic circular dichroism (ECD) spectra and comparison with known compounds. Compound 1 was derived from an analogue of compound 2 by cyclization, while a retro-Claisen reaction transformed another analogue of compound 2 into compound 3. Compounds 3, 4, 5, and 10 showed obvious hepatoprotective activities against paracetamol-induced HepG2 cell damage. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：4932 / 4936

页数：5

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