A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure

被引：26

作者：

Wit, Jan M. ^{[1
]}

Bidlingmaier, Martin ^{[2
]}

de Bruin, Christiaan ^{[1
]}

Oostdijk, Wilma ^{[1
]}

机构：

[1] Leiden Univ, Dept Paediat, Med Ctr, Leiden, Netherlands

[2] Klinikum Univ Munchen, Endocrine Res Labs, Med Klin & Poliklin 4, Munich, Germany

来源：

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY | 2020年 / 12卷 / 02期

关键词：

Short stature; growth disorders; IGF-I; IGFBP-3; HORMONE DEFICIENCY; SHORT STATURE; GENETIC EVALUATION; BINDING PROTEIN-3; DIAGNOSTIC-VALUE; CELIAC-DISEASE; CHILDHOOD; ENDOCRINE; PREVALENCE; IGFBP-3;

D O I：

10.4274/jcrpe.galenos.2019.2019.0176

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The serum insulin-like growth factor-I (IGF-I) concentration is commonly used as a screening tool for growth hormone deficiency (GHD), but there is no consensus on the cut-off limit of IGF-I standard deviation score (SDS) to perform GH stimulation tests for confirmation or exclusion of GHD. We argue that the cut-off limit is dependent on the clinical pre-test likelihood of GHD and propose a diagnostic strategy in which the cut-off limit varies between zero to -2 SDS.

引用

页码：130 / 139

页数：10

共 54 条

[1] GROWTH-HORMONE NEUROSECRETORY DYSFUNCTION [J].

BERCU, BB ;

DIAMOND, FB .

CLINICS IN ENDOCRINOLOGY AND METABOLISM, 1986, 15 (03) :537-590

[2] GROWTH-HORMONE (GH) PROVOCATIVE TESTING FREQUENTLY DOES NOT REFLECT ENDOGENOUS GH SECRETION [J].

BERCU, BB ;

SHULMAN, D ;

ROOT, AW ;

SPILIOTIS, BE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 63 (03) :709-716

[3] Does every short stature child need screening for celiac disease? [J].

Bhadada, Sanjay Kumar ;

Bhansali, Anil ;

Kochhar, Rakesh ;

Menon, Anil Shankar ;

Sinha, Saroj Kant ;

Dutta, Pinaki ;

Nain, Chander Kanwal .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2008, 23 (08) :E353-E356

[4] Changing Scenario in Aetiological Profile of Short Stature in India-Growing Importance of Celiac Disease: A Study from Tertiary Care Centre [J].

Bhadada, Sanjay Kumar ;

Bhansali, Anil ;

RaviKumar, Padala ;

Kochhar, Rakesh ;

Nain, Chandra Kant ;

Dutta, Pinaki ;

Lal, Sadhna .

INDIAN JOURNAL OF PEDIATRICS, 2011, 78 (01) :41-44

[5] Reference Intervals for Insulin-like Growth Factor-1 (IGF-I) From Birth to Senescence: Results From a Multicenter Study Using a New Automated Chemiluminescence IGF-I Immunoassay Conforming to Recent International Recommendations [J].

Bidlingmaier, Martin ;

Friedrich, Nele ;

Emeny, Rebecca T. ;

Spranger, Joachim ;

Wolthers, Ole D. ;

Roswall, Josefine ;

Koerner, Antje ;

Obermayer-Pietsch, Barbara ;

Huebener, Christoph ;

Dahlgren, Jovanna ;

Frystyk, Jan ;

Pfeiffer, Andreas F. H. ;

Doering, Angela ;

Bielohuby, Maximilian ;

Wallaschofski, Henri ;

Arafat, Ayman M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (05) :1712-1721

[6] Rational Approach to the Diagnosis of Severe Growth Hormone Deficiency in the Newborn [J].

Binder, G. ;

Weidenkeller, M. ;

Blumenstock, G. ;

Langkamp, M. ;

Weber, K. ;

Franz, A. R. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (05) :2219-2226

[7] Early retesting by GHRH plus arginine test shows normal GH response in most children with idiopathic GH deficiency [J].

Bizzarri, C. ;

Pedicelli, S. ;

Boscherini, B. ;

Bedogni, G. ;

Cappa, M. ;

Cianfarani, S. .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2015, 38 (04) :429-436

[8] The growth hormone-insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders [J].

Blum, Werner F. ;

Alherbish, Abdullah ;

Alsagheir, Afaf ;

El Awwa, Ahmed ;

Kaplan, Walid ;

Koledova, Ekaterina ;

Savage, Martin O. .

ENDOCRINE CONNECTIONS, 2018, 7 (06) :R212-R222

[9] Consensus Statement on the Diagnosis and Treatment of Children with Idiopathic Short Stature: A Summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop [J].

Cohen, P. ;

Rogol, A. D. ;

Deal, C. L. ;

Saenger, P. ;

Reiter, E. O. ;

Ross, J. L. ;

Chernausek, S. D. ;

Savage, M. O. ;

Wit, J. M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (11) :4210-4217

[10] Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective [J].

Collett-Solberg, Paulo F. ;

Ambler, Geoffrey ;

Backeljauw, Philippe F. ;

Bidlingmaier, Martin ;

Biller, Beverly M. K. ;

Boguszewski, Margaret C. S. ;

Cheung, Pik To ;

Choong, Catherine Seut Yhoke ;

Cohen, Laurie E. ;

Cohen, Pinchas ;

Dauber, Andrew ;

Deal, Cheri L. ;

Gong, Chunxiu ;

Hasegawa, Yukihiro ;

Hoffman, Andrew R. ;

Hofman, Paul L. ;

Horikawa, Reiko ;

Jorge, Alexander A. L. ;

Juul, Anders ;

Kamenicky, Peter ;

Khadilkar, Vaman ;

Kopchick, John J. ;

Kristrom, Berit ;

Lopes, Maria de Lurdes A. ;

Luo, Xiaoping ;

Miller, Bradley S. ;

Misra, Madhusmita ;

Netchine, Irene ;

Radovick, Sally ;

Ranke, Michael B. ;

Rogol, Alan D. ;

Rosenfeld, Ron G. ;

Saenger, Paul ;

Wit, Jan M. ;

Woelfle, Joachim .

HORMONE RESEARCH IN PAEDIATRICS, 2019, 92 (01) :1-14

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