The thyroid hormone receptor β gene:: Structure and functions in the brain and sensory systems

被引：62
作者：
Jones, I [1 ]
Srinivas, M [1 ]
Ng, L [1 ]
Forrest, D [1 ]
机构：
[1] CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA
来源：
THYROID | 2003年 / 13卷 / 11期
关键词：
EMBRYONIC STEM-CELLS; RAT-BRAIN; C-ERBA; NUCLEAR RECEPTOR; XENOPUS-LAEVIS; TRANSCRIPTIONAL REGULATION; POSTNATAL-DEVELOPMENT; AUDIOGENIC-SEIZURES; MESSENGER-RNAS; PHOTORECEPTOR DEVELOPMENT;
D O I：
10.1089/105072503770867228
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thyroid hormone profoundly influences the development of the vertebrate nervous system. The thyroid hormone receptor beta gene (Thrb) is a key mediator of many of these actions. The Thrb gene is complex, spanning up to 400 kb in mammals, and differentially expresses distinct receptor subtypes through independent tissue-specific promoters and alternative splicing. These receptors serve a range of functions in the brain as well as particularly sensitive functions in the auditory and visual sensory systems. The Thrb gene illustrates how versatility in neurodevelopmental control can be achieved at the receptor level.
引用
收藏
页码：1057 / 1068
页数：12
相关论文
共 154 条
  • [1] Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system
    Abel, ED
    Boers, ME
    Pazos-Moura, C
    Moura, E
    Kaulbach, H
    Zakaria, M
    Lowell, B
    Radovick, S
    Liberman, MC
    Wondisford, F
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (03) : 291 - 300
  • [2] Critical role for thyroid hormone receptor β2 in the regulation of paraventricular thyrotropin-releasing hormone neurons
    Abel, ED
    Ahima, RS
    Boers, ME
    Elmquist, JK
    Wondisford, FE
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (08) : 1017 - 1023
  • [3] An emilin family extracellular matrix protein identified in the cochlear basilar membrane
    Amma, LL
    Goodyear, R
    Faris, JS
    Jones, I
    Ng, L
    Richardson, G
    Forrest, D
    [J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 23 (03) : 460 - 472
  • [4] Distinct tissue-specific roles for thyroid hormone receptors β and α1 in regulation of type 1 deiodinase expression
    Amma, LL
    Campos-Barros, A
    Wang, ZD
    Vennström, B
    Forrest, D
    [J]. MOLECULAR ENDOCRINOLOGY, 2001, 15 (03) : 467 - 475
  • [5] [Anonymous], [No title captured], DOI DOI 10.1210/JCEM.85.11.6961
  • [6] THE EFFECTS OF CONGENITAL HYPOTHYROIDISM USING THE HYT/HYT MOUSE ON LOCOMOTOR-ACTIVITY AND LEARNED BEHAVIOR
    ANTHONY, A
    ADAMS, PM
    STEIN, SA
    [J]. HORMONES AND BEHAVIOR, 1993, 27 (03) : 418 - 433
  • [7] Auwerx J, 1999, CELL, V97, P161
  • [8] Thyroid-β2 and the retinoid RAR-α, RXR-γ and ROR-β2 receptor mRNAs;: expression profiles in mouse retina, retinal explants and neocortex
    Azadi, S
    Zhang, Y
    Caffé, AR
    Holmqvist, B
    van Veen, T
    [J]. NEUROREPORT, 2002, 13 (06) : 745 - 750
  • [9] Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors
    Baas, D
    Legrand, C
    Samarut, J
    Flamant, F
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (05) : 2907 - 2911
  • [10] The type 2 and type 3 iodothyronine deiodinases play important roles in coordinating development in Rana catesbeiana tadpoles
    Becker, KB
    Stephens, KC
    Davey, JC
    Schneider, MJ
    Galton, VA
    [J]. ENDOCRINOLOGY, 1997, 138 (07) : 2989 - 2997
12345678910