Immunogenicity of meningococcal polysaccharide conjugate vaccine as a replacement for meningococcal polysaccharide vaccine in children in Guangzhou, China

被引：2

作者：

He, Qing ^{[1
]}

Xiao, Jiali ^{[2
]}

Liu, Meizhen ^{[3
]}

Li, Zhencui ^{[3
]}

Xu, Jiangxiong ^{[1
]}

Zhang, Zhoubin ^{[1
]}

机构：

[1] Guangzhou Ctr Dis Control & Prevent, Guangzhou 510440, Peoples R China

[2] Guangzhou Tianhe Ctr Dis Control & Prevent, Guangzhou 510655, Peoples R China

[3] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 511430, Peoples R China

来源：

VACCINE | 2022年 / 40卷 / 09期

关键词：

vaccine; Meningococcal polysaccharide vaccine; Immunogenicity; Persistence; Meningococcal polysaccharide conjugate vaccine; PREVENTION; DISEASE;

D O I：

10.1016/j.vaccine.2021.09.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To assess the durability of antibody persistence after substitution of the MPCV vaccine for the MPSV-A vaccine in children, an observational study was conducted in children who voluntarily received two doses of MPCV-AC instead of MPSV-A between March 2017 and March 2018 in Guangzhou, China. In total, 131 and 47 participants were enrolled in the 3-year-old and 6-year-old groups, respectively. In the 3-year-old group, the seroprotection rate and GMT values for Men A and Men C were raised significantly after 1 month post-dose 1 MPSV booster vaccination. All immune indicators were significantly lower in pre dose 1 MPSV booster vaccination in the 3-year-old group than after pre-dose 2 MPSV booster vaccination in the 6-year-old group. While no significant differences were found in most immune indicators between the 1-month post-dose 1 MPSV booster vaccination in the 3-year-old group and pre-dose 2 MPSV booster vaccination in 6-year-old group. The substitute meningococcal immunization schedule showed a good immunogenicity in young children, and good sequential immunogenicity with MPSV booster immunization. (c) 2021 Published by Elsevier Ltd.

引用

页码：1370 / 1375

页数：6

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